Description
Compare a supplied concentration with an explicit limit and equality policy.
Pharmacokinetic records distinguish concentration, amount, elapsed time, dilution basis and assay quantification status. Multiplying concentration by compatible volume gives an amount, while a first-order decay factor assumes a supplied constant rate. These local terms and labels do not estimate a person's drug exposure or establish a dose, therapeutic threshold or safe medication decision.
Compare a supplied concentration with an explicit limit and equality policy.
When to use this tool
Use PK Time Above Limit Flag when you already have concentration, explicitLimit, equalityCounts and need to compare a supplied concentration with an explicit limit and equality policy.
How to use the tool and how it works
- Enter concentration, explicitLimit, equalityCounts. Use the units and conventions below.
- Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
- Read aboveUnderPolicy. Inspect aboveUnderPolicy before interpreting the associated values.
Require nonnegative concentration/limit; compare >, or >= when equalityCounts=true.1
| Input field | Meaning and units | Accepted input |
|---|---|---|
| concentration | Concentration | Required. Finite number; minimum 0. |
| explicitLimit | Explicit Limit | Required. Finite number; minimum 0. |
| equalityCounts | Equality Counts | Required. Boolean. |
| Output field | Interpretation | Returned shape |
|---|---|---|
| aboveUnderPolicy | Single supplied concentration comparison, not time above a threshold. | Required. Boolean. |
{
"input": {
"concentration": 4,
"explicitLimit": 3,
"equalityCounts": false
},
"output": {
"aboveUnderPolicy": true
}
}Limitations and assumptions
- This tests one concentration only, not duration above a limit; no therapeutic threshold, dose, safety or medication decision is selected.
- Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
- Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Numeric signed-zero results are exported as zero.
Alternative or Complementary methods
Use verified assay data and an appropriate complete pharmacokinetic model for exposure analysis. Keep dilution, concentration/amount units, sampling time and quantification conventions attached to the observations; a scalar decay or limit comparison does not estimate a regimen.
References
Similar or alternative tools
- PK Below Quantification Label
Label a sample's supplied below-quantification flag.
- PD Ceiling Floor Censoring Label
Label a supplied floor/ceiling censoring convention.