Description
Calculate free fraction as the complement of a supplied occupancy fraction.
Assay records separate concentration/effect units, control references, censoring and model parameters. An occupied/free complement assumes one common exhaustive total, while a control ratio is not automatically a percentage effect. Labels and local scalar operations do not fit a response model or establish potency, drug efficacy or an appropriate medication choice.
Calculate free fraction as the complement of a supplied occupancy fraction.
When to use this tool
Use PD Occupancy To Free Fraction when you already have occupiedFraction and need to calculate free fraction as the complement of a supplied occupancy fraction.
How to use the tool and how it works
- Enter occupiedFraction. Use the units and conventions below.
- Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
- Read freeFraction. Use the output convention below.
Require occupiedFraction in [0,1]; return 1-occupiedFraction.1
| Input field | Meaning and units | Accepted input |
|---|---|---|
| occupiedFraction | Supplied fraction of the same exhaustive total used for freeFraction. | Required. Finite number; minimum 0; maximum 1. |
| Output field | Interpretation | Returned shape |
|---|---|---|
| freeFraction | Free Fraction | Required. Finite number. |
{
"input": {
"occupiedFraction": 0.75
},
"output": {
"freeFraction": 0.25
}
}Limitations and assumptions
- Assumes occupied and free exhaust the same reference total; no binding model, concentration, receptor state or drug response is estimated.
- Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
- Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Numeric signed-zero results are exported as zero.
Alternative or Complementary methods
Use the full assay controls, measurement units and response-model definition when estimating an effect. Fit or evaluate the intended concentration-response relationship explicitly; a control ratio, complement or parameter label does not infer that relationship.
References
Similar or alternative tools
- PD Assay Control Relative Value
Calculate an assay value relative to a nonzero supplied control.
- PD Concentration Effect Pair Unit
Qualify an explicit concentration-effect pair by supplied units.