Cone Bioassay Mortality

Compute Abbott-corrected cone-bioassay mortality and compare with a caller-defined criterion.

Description

Cone-bioassay mortality can be corrected for deaths observed in a control group.

Cone-bioassay mortality can be corrected for deaths observed in a control group. The correction estimates excess mortality relative to surviving controls.

The tool returns rawMortalityFraction (raw mortality fraction); controlMortalityFraction (control mortality fraction); correctedMortalityFraction (corrected mortality fraction); meetsSuppliedCriterion (meets supplied criterion). Input measurements and model parameters are supplied by the caller; the tool computes the stated summary rather than acquiring those measurements.

When to use Cone Bioassay Mortality

Use Cone Bioassay Mortality when you already have treatedDead, treatedExposed, controlDead, controlExposed, minimumCorrectedMortality and want rawMortalityFraction, controlMortalityFraction, correctedMortalityFraction, meetsSuppliedCriterion. This is useful for checking a supplied calculation, documenting a measurement convention, or comparing observations prepared on the same basis.

How to use Cone Bioassay Mortality and understand its results

Enter treatedDead, treatedExposed, controlDead, controlExposed, minimumCorrectedMortality using the field table below. Match the units, ordering and data boundaries described in the calculation.
Run the tool after checking the stated bounds and matching paired observations or categories. A malformed request gives a tool error rather than a usable measurement.
Read rawMortalityFraction, controlMortalityFraction, correctedMortalityFraction, meetsSuppliedCriterion. Use the calculation and interpretation below to distinguish amounts, ratios, signs and decision flags where applicable.
Review the supplied parameters and assumptions before using the result in a report or comparing it with another observation.

Input field	Meaning	Value type and bounds	Requirement
treatedDead	Treated dead	integer	Required
treatedExposed	Treated exposed	integer	Required
controlDead	Control dead	integer	Required
controlExposed	Control exposed	integer	Required
minimumCorrectedMortality	Minimum corrected mortality	number	Required

Validate dead counts against positive exposed totals, requiring control mortality below 100%. Return raw and corrected values, then compare with the supplied criterion inclusively.

corrected mortality = max(0, (treatedFraction − controlFraction)/(1 − controlFraction))

The symbols refer to the supplied quantities or generated values described above; unit conversions and comparison boundaries follow the stated implementation.

json

{
  "input": {
    "treatedDead": 90,
    "treatedExposed": 100,
    "controlDead": 10,
    "controlExposed": 100,
    "minimumCorrectedMortality": 0.8
  },
  "output": {
    "rawMortalityFraction": 0.9,
    "controlMortalityFraction": 0.1,
    "correctedMortalityFraction": 0.888888888888889,
    "meetsSuppliedCriterion": true
  }
}

Limitations and assumptions

No protocol-specific rule for discarding high-control-mortality experiments is enforced. The caller must review assay validity and applicable guidance.

Numerical inputs must be finite. The tool checks its declared input shape and calculation constraints; those checks do not verify the quality, calibration or representativeness of the supplied observations.

Alternative or Complementary methods

PBO Synergy Ratio: Compare insecticide mortality with and without PBO; a ratio alone does not identify resistance mechanism. Net Use Adherence: Apply a caller-defined reliability factor to reported insecticide-treated-net use.

Methodological background: Deforestation and Vectorial Capacity of Anopheles gambiae Mosquitoes in Malaria Transmission, Kenya.^[1]

References

Deforestation and Vectorial Capacity of Anopheles gambiae Mosquitoes in Malaria Transmission, Kenya — Afrane et al.; Emerging Infectious Diseases

Similar or alternative tools

PBO Synergy Ratio
Compare insecticide mortality with and without PBO; a ratio alone does not identify resistance mechanism.
Net Use Adherence
Apply a caller-defined reliability factor to reported insecticide-treated-net use.