Adenylate Energy Charge
Calculate adenylate energy charge from ATP, ADP, and AMP.
Description
Adenylate energy charge weights ATP fully and ADP halfway within the measured adenylate pool.
Adenylate energy charge weights ATP fully and ADP halfway within the measured adenylate pool. The normalized value ranges from zero to one for nonnegative inputs.1
Calculate adenylate energy charge from ATP, ADP, and AMP.
When to use Adenylate Energy Charge
Use this tool to calculate adenylate energy charge from ATP, ADP, and AMP.
Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.
How to use Adenylate Energy Charge and understand its results
- Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.
- Enter atp, adp, amp using the field table and calculation rules, then run the tool.
- Read energyCharge, totalAdenylates. The explanation below defines the units, signs, ordering and any flags or placeholder values.
- If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.
| Input field | Meaning | Value type; see rules below | Requirement |
|---|---|---|---|
| atp | Atp | number | Required |
| adp | Adp | number | Required |
| amp | Amp | number | Required |
Enter nonnegative compatible nucleotide amounts with positive total. Return energy charge and total pool.
charge=(ATP+0.5 ADP)/(ATP+ADP+AMP) Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.
| Output field | Meaning | Value type |
|---|---|---|
| energyCharge | Energy charge | number |
| totalAdenylates | Total adenylates | number |
{
"input": {
"atp": 2,
"adp": 2,
"amp": 2
},
"output": {
"energyCharge": 0.5,
"totalAdenylates": 6
}
}Limitations and assumptions
No compartment separation, ATP flux or physiological threshold is supplied.
Numeric inputs must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors.
Alternative or Complementary methods
Use Adenylate Kinase Quotient: Check adenylate kinase mass-action quotient against an injected equilibrium value. For a complementary task, use SAM SAH Ratio: Screen methylation potential with a supplied SAM/SAH cutoff.
References
-
Adenylate Energy Charge — tool.io
Similar or alternative tools
- Adenylate Kinase Quotient
Check adenylate kinase mass-action quotient against an injected equilibrium value.
- SAM SAH Ratio
Screen methylation potential with a supplied SAM/SAH cutoff.