X Dominant Daughter Evidence

Audit affected-father daughter observations against a fully penetrant X-dominant model.

Description

Under a fully penetrant X-dominant model, an affected father transmits the relevant X to his daughters.

Under a fully penetrant X-dominant model, an affected father transmits the relevant X to his daughters. Observations can be audited against that specific prediction.^[1]

Audit affected-father daughter observations against a fully penetrant X-dominant model.

When to use X Dominant Daughter Evidence

Use this for the following task: Audit affected-father daughter observations against a fully penetrant X-dominant model.

Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.

How to use X Dominant Daughter Evidence and understand its results

Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
Enter affectedFatherIds, daughterCounts, affectedDaughterCounts using the field table, then run the tool.
Read allDaughtersAffectedFathers, contradictoryFatherIds, allAssessedFamiliesConsistent. Interpret flags, units, ordering and placeholder values using the rules below.
Review any reported issue or failed check, correct the supplied values when appropriate, and verify the result in its intended context.

Input field	Meaning	Value type and bounds	Requirement
affectedFatherIds	Affected father ids	list of string; each entry: string	Required
daughterCounts	Daughter counts	list of number; each entry: number	Required
affectedDaughterCounts	Affected daughter counts	list of number; each entry: number	Required

Align affected-father IDs with positive daughter totals and nonnegative affected counts bounded by each total. Return consistent and contradictory father lists.^[2]

consistent father when affectedDaughters == daughterCount

This summarizes the declared operation. Units, indexing, inclusivity and exceptional cases are explained in the surrounding text.

Output field	Meaning	Value type
allDaughtersAffectedFathers	All daughters affected fathers	list of string
contradictoryFatherIds	Contradictory father ids	list of string
allAssessedFamiliesConsistent	All assessed families consistent	boolean

json

{
  "input": {
    "affectedFatherIds": [
      "A",
      "B"
    ],
    "daughterCounts": [
      2,
      1
    ],
    "affectedDaughterCounts": [
      2,
      0
    ]
  },
  "output": {
    "allDaughtersAffectedFathers": [
      "A"
    ],
    "contradictoryFatherIds": [
      "B"
    ],
    "allAssessedFamiliesConsistent": false
  }
}

Limitations and assumptions

The model assumes complete penetrance and reliable family/phenotype data. Consistency does not prove X-linked inheritance.

The tool evaluates supplied observations or a declared model. It does not establish the biological cause of an observed pattern. Malformed requests produce input errors. A successfully evaluated request can still contain false flags, empty result lists or a result outside the supplied threshold; those outcomes have the meanings stated above.

Alternative or Complementary methods

Choose Father Son Transmission Evidence for this operation: Audit whether documented transmission edges are exclusively father-to-son. For a complementary task, use Dominant Generation Pedigree Pattern for this operation: Summarize consecutive affected pedigree generations as evidence consistent with vertical inheritance.

Further background: Inheritance patterns.

References

Inheritance patterns — National Library of Medicine
X Dominant Daughter Evidence — tool.io

Similar or alternative tools

Father Son Transmission Evidence
Audit whether documented transmission edges are exclusively father-to-son.
Dominant Generation Pedigree Pattern
Summarize consecutive affected pedigree generations as evidence consistent with vertical inheritance.