Dominant Generation Pedigree Pattern

Summarize consecutive affected pedigree generations as evidence consistent with vertical inheritance.

Description

Affected individuals in consecutive pedigree generations form a vertical pattern.

Affected individuals in consecutive pedigree generations form a vertical pattern. Summarizing that pattern can guide inheritance review without proving dominance.^[1]

Summarize consecutive affected pedigree generations as evidence consistent with vertical inheritance.

When to use Dominant Generation Pedigree Pattern

Use this for the following task: Summarize consecutive affected pedigree generations as evidence consistent with vertical inheritance.

Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.

How to use Dominant Generation Pedigree Pattern and understand its results

Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
Enter generationIndexes, affectedFlags using the field table, then run the tool.
Read affectedGenerations, longestAffectedRun, verticalPattern. Interpret flags, units, ordering and placeholder values using the rules below.
Review any reported issue or failed check, correct the supplied values when appropriate, and verify the result in its intended context.

Input field	Meaning	Value type and bounds	Requirement
generationIndexes	Generation indexes	list of number; each entry: number	Required
affectedFlags	Affected flags	list of number; each entry: number	Required

Align nonnegative integer generations with numeric 0/1 affected flags. Deduplicate and sort affected generations, then count the longest consecutive run.^[2]

verticalPattern = longest consecutive affected-generation run ≥ 2

This summarizes the declared operation. Units, indexing, inclusivity and exceptional cases are explained in the surrounding text.

Output field	Meaning	Value type
affectedGenerations	Affected generations	list of number
longestAffectedRun	Longest affected run	number
verticalPattern	Vertical pattern	boolean

json

{
  "input": {
    "generationIndexes": [
      0,
      1,
      2,
      2
    ],
    "affectedFlags": [
      1,
      1,
      1,
      0
    ]
  },
  "output": {
    "affectedGenerations": [
      0,
      1,
      2
    ],
    "longestAffectedRun": 3,
    "verticalPattern": true
  }
}

Limitations and assumptions

Family relationships, penetrance and ascertainment are absent. Multiple affected people in one generation do not increase the run length.

The tool evaluates supplied observations or a declared model. It does not establish the biological cause of an observed pattern. Malformed requests produce input errors. A successfully evaluated request can still contain false flags, empty result lists or a result outside the supplied threshold; those outcomes have the meanings stated above.

Alternative or Complementary methods

Choose Recessive Sibling Pedigree Pattern for this operation: Locate affected-sibling clusters with unaffected parents; pattern evidence is not proof of recessive inheritance. For a complementary task, use X Dominant Daughter Evidence for this operation: Audit affected-father daughter observations against a fully penetrant X-dominant model.

Further background: Inheritance patterns.

References

Inheritance patterns — National Library of Medicine
Dominant Generation Pedigree Pattern — tool.io

Similar or alternative tools

Recessive Sibling Pedigree Pattern
Locate affected-sibling clusters with unaffected parents; pattern evidence is not proof of recessive inheritance.
X Dominant Daughter Evidence
Audit affected-father daughter observations against a fully penetrant X-dominant model.