Father Son Transmission Evidence
Audit whether documented transmission edges are exclusively father-to-son.
Description
Father-to-son transmission edges are one observable pedigree pattern.
Father-to-son transmission edges are one observable pedigree pattern. Auditing those edges describes evidence without establishing a chromosomal cause.1
Audit whether documented transmission edges are exclusively father-to-son.
When to use Father Son Transmission Evidence
Use this for the following task: Audit whether documented transmission edges are exclusively father-to-son.
Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
How to use Father Son Transmission Evidence and understand its results
- Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
- Enter parentSexes, childSexes using the field table, then run the tool.
- Read fatherSonCount, inconsistentEdgeIndexes, fatherSonOnlyObserved. Interpret flags, units, ordering and placeholder values using the rules below.
- Review any reported issue or failed check, correct the supplied values when appropriate, and verify the result in its intended context.
| Input field | Meaning | Value type and bounds | Requirement |
|---|---|---|---|
| parentSexes | Parent sexes | list of string; each entry: string | Required |
| childSexes | Child sexes | list of string; each entry: string | Required |
Align explicit male/female parent and child labels for documented transmissions. Count male-to-male edges and return zero-based indices of every other edge.2
fatherSonOnlyObserved = every parent and child label is male This summarizes the declared operation. Units, indexing, inclusivity and exceptional cases are explained in the surrounding text.
| Output field | Meaning | Value type |
|---|---|---|
| fatherSonCount | Father son count | number |
| inconsistentEdgeIndexes | Inconsistent edge indexes | list of number |
| fatherSonOnlyObserved | Father son only observed | boolean |
{
"input": {
"parentSexes": [
"male",
"male",
"female"
],
"childSexes": [
"male",
"female",
"male"
]
},
"output": {
"fatherSonCount": 1,
"inconsistentEdgeIndexes": [
1,
2
],
"fatherSonOnlyObserved": false
}
}Limitations and assumptions
The tool does not establish Y-linkage or rule out autosomal inheritance.
The tool evaluates supplied observations or a declared model. It does not establish the biological cause of an observed pattern. Malformed requests produce input errors. A successfully evaluated request can still contain false flags, empty result lists or a result outside the supplied threshold; those outcomes have the meanings stated above.
Alternative or Complementary methods
Choose Maternal Transmission Evidence for this operation: Audit documented transmission edges for maternal-only inheritance, without establishing mitochondrial causation. For a complementary task, use X Dominant Daughter Evidence for this operation: Audit affected-father daughter observations against a fully penetrant X-dominant model.
Further background: Inheritance patterns.
References
-
Inheritance patterns — National Library of Medicine
-
Father Son Transmission Evidence — tool.io
Similar or alternative tools
- Maternal Transmission Evidence
Audit documented transmission edges for maternal-only inheritance, without establishing mitochondrial causation.
- X Dominant Daughter Evidence
Audit affected-father daughter observations against a fully penetrant X-dominant model.