RH Incompatibility Cross
Model Rh-D-positive offspring and maternal Rh incompatibility, not sensitization or disease probability.
Description
A simplified Rh-D cross treats D as dominant over d.
A simplified Rh-D cross treats D as dominant over d. Maternal dd with a D-positive offspring supplies an incompatibility pattern under this model.1
Model Rh-D-positive offspring and maternal Rh incompatibility, not sensitization or disease probability.
When to use RH Incompatibility Cross
Use this for the following task: Model Rh-D-positive offspring and maternal Rh incompatibility, not sensitization or disease probability.
Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
How to use RH Incompatibility Cross and understand its results
- Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
- Enter motherGenotype, fatherGenotype using the field table, then run the tool.
- Read rhPositiveOffspringProbability, rhIncompatiblePregnancyProbability. Interpret flags, units, ordering and placeholder values using the rules below.
- Review any reported issue or failed check, correct the supplied values when appropriate, and verify the result in its intended context.
| Input field | Meaning | Value type and bounds | Requirement |
|---|---|---|---|
| motherGenotype | Mother genotype | string | Required |
| fatherGenotype | Father genotype | string | Required |
Choose exact DD, Dd or dd genotypes. Enumerate the four allele-choice cells and return the two probabilities.2
Rh-positive probability = D-containing offspring cells/4; incompatibility = same probability only when mother is dd This summarizes the declared operation. Units, indexing, inclusivity and exceptional cases are explained in the surrounding text.
| Output field | Meaning | Value type |
|---|---|---|
| rhPositiveOffspringProbability | Rh positive offspring probability | number |
| rhIncompatiblePregnancyProbability | Rh incompatible pregnancy probability | number |
{
"input": {
"motherGenotype": "dd",
"fatherGenotype": "Dd"
},
"output": {
"rhPositiveOffspringProbability": 0.5,
"rhIncompatiblePregnancyProbability": 0.5
}
}Limitations and assumptions
This does not estimate sensitization or hemolytic disease probability and excludes variant Rh genetics.
The tool evaluates supplied observations or a declared model. It does not establish the biological cause of an observed pattern. Malformed requests produce input errors. A successfully evaluated request can still contain false flags, empty result lists or a result outside the supplied threshold; those outcomes have the meanings stated above.
Alternative or Complementary methods
Choose ABO Genotype Cross for this operation: Resolve Mendelian ABO phenotype probabilities from the supplied parental allele pairs. For a complementary task, use Weighted Gamete Grid for this operation: Build a weighted gamete-combination grid allowing caller-supplied transmission probabilities.
Further background: Inheritance patterns.
References
-
Inheritance patterns — National Library of Medicine
-
RH Incompatibility Cross — tool.io
Similar or alternative tools
- ABO Genotype Cross
Resolve Mendelian ABO phenotype probabilities from the supplied parental allele pairs.
- Weighted Gamete Grid
Build a weighted gamete-combination grid allowing caller-supplied transmission probabilities.