ABO Genotype Cross

Resolve Mendelian ABO phenotype probabilities from the supplied parental allele pairs.

Description

A simplified ABO cross maps A and B alleles to codominant expression and O to the recessive phenotype.

A simplified ABO cross maps A and B alleles to codominant expression and O to the recessive phenotype. Parental genotypes determine the Mendelian cell probabilities.^[1]

Resolve Mendelian ABO phenotype probabilities from the supplied parental allele pairs.

When to use ABO Genotype Cross

Use this for the following task: Resolve Mendelian ABO phenotype probabilities from the supplied parental allele pairs.

Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.

How to use ABO Genotype Cross and understand its results

Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
Enter firstParentGenotype, secondParentGenotype using the field table, then run the tool.
Read phenotypes, phenotypeProbabilities. Interpret flags, units, ordering and placeholder values using the rules below.
Review any reported issue or failed check, correct the supplied values when appropriate, and verify the result in its intended context.

Input field	Meaning	Value type and bounds	Requirement
firstParentGenotype	First parent genotype	string	Required
secondParentGenotype	Second parent genotype	string	Required

Choose exact AA, AO, BB, BO, AB or OO parent genotypes. Enumerate four allele-choice cells and return probabilities in fixed A,B,AB,O order, including zero categories.^[2]

offspring cell probability = 1/4; accumulate into A,B,AB,O

This summarizes the declared operation. Units, indexing, inclusivity and exceptional cases are explained in the surrounding text.

Output field	Meaning	Value type
phenotypes	Phenotypes	list of string
phenotypeProbabilities	Phenotype probabilities	list of number

json

{
  "input": {
    "firstParentGenotype": "AO",
    "secondParentGenotype": "BO"
  },
  "output": {
    "phenotypes": [
      "A",
      "B",
      "AB",
      "O"
    ],
    "phenotypeProbabilities": [
      0.25,
      0.25,
      0.25,
      0.25
    ]
  }
}

Limitations and assumptions

Rare alleles, Bombay phenotype and nonstandard inheritance are excluded. The tool does not determine genotypes from blood typing.

The tool evaluates supplied observations or a declared model. It does not establish the biological cause of an observed pattern. Malformed requests produce input errors. A successfully evaluated request can still contain false flags, empty result lists or a result outside the supplied threshold; those outcomes have the meanings stated above.

Alternative or Complementary methods

Choose RH Incompatibility Cross for this operation: Model Rh-D-positive offspring and maternal Rh incompatibility, not sensitization or disease probability. For a complementary task, use Phenotype Class Aggregation for this operation: Aggregate genotype-class probabilities into caller-defined phenotype percentages.

Further background: Inheritance patterns.

References

Inheritance patterns — National Library of Medicine
ABO Genotype Cross — tool.io

Similar or alternative tools

RH Incompatibility Cross
Model Rh-D-positive offspring and maternal Rh incompatibility, not sensitization or disease probability.
Phenotype Class Aggregation
Aggregate genotype-class probabilities into caller-defined phenotype percentages.