Maternal Transmission Evidence
Audit documented transmission edges for maternal-only inheritance, without establishing mitochondrial causation.
Description
Maternal-only documented transmission is compatible with some inheritance models.
Maternal-only documented transmission is compatible with some inheritance models. It describes the observed edges without establishing mitochondrial causation.1
Audit documented transmission edges for maternal-only inheritance, without establishing mitochondrial causation.
When to use Maternal Transmission Evidence
Use this for the following task: Audit documented transmission edges for maternal-only inheritance, without establishing mitochondrial causation.
Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
How to use Maternal Transmission Evidence and understand its results
- Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
- Enter transmittingParentSexes, offspringSexes using the field table, then run the tool.
- Read maternalTransmissionCount, paternalTransmissionIndexes, maternalOnlyObserved. Interpret flags, units, ordering and placeholder values using the rules below.
- Review any reported issue or failed check, correct the supplied values when appropriate, and verify the result in its intended context.
| Input field | Meaning | Value type and bounds | Requirement |
|---|---|---|---|
| transmittingParentSexes | Transmitting parent sexes | list of string; each entry: string | Required |
| offspringSexes | Offspring sexes | list of string; each entry: string | Required |
Align explicit male/female labels for transmitting parents and offspring. Count female-parent transmissions and return zero-based paternal-edge indices.2
maternalOnlyObserved = no male transmitting-parent entries This summarizes the declared operation. Units, indexing, inclusivity and exceptional cases are explained in the surrounding text.
| Output field | Meaning | Value type |
|---|---|---|
| maternalTransmissionCount | Maternal transmission count | number |
| paternalTransmissionIndexes | Paternal transmission indexes | list of number |
| maternalOnlyObserved | Maternal only observed | boolean |
{
"input": {
"transmittingParentSexes": [
"female",
"female",
"male"
],
"offspringSexes": [
"male",
"female",
"male"
]
},
"output": {
"maternalTransmissionCount": 2,
"paternalTransmissionIndexes": [
2
],
"maternalOnlyObserved": false
}
}Limitations and assumptions
Transmission must already be documented rather than inferred from phenotype coincidence. No mitochondrial genotype or heteroplasmy analysis is performed.
The tool evaluates supplied observations or a declared model. It does not establish the biological cause of an observed pattern. Malformed requests produce input errors. A successfully evaluated request can still contain false flags, empty result lists or a result outside the supplied threshold; those outcomes have the meanings stated above.
Alternative or Complementary methods
Choose Father Son Transmission Evidence for this operation: Audit whether documented transmission edges are exclusively father-to-son. For a complementary task, use X Dominant Daughter Evidence for this operation: Audit affected-father daughter observations against a fully penetrant X-dominant model.
Further background: Inheritance patterns.
References
-
Inheritance patterns — National Library of Medicine
-
Maternal Transmission Evidence — tool.io
Similar or alternative tools
- Father Son Transmission Evidence
Audit whether documented transmission edges are exclusively father-to-son.
- X Dominant Daughter Evidence
Audit affected-father daughter observations against a fully penetrant X-dominant model.