Codominant Expression Screen
Screen distinct allele-marker signals for simultaneous expression at a caller-defined detection threshold.
Description
Separate allele-marker signals can show simultaneous expression.
Separate allele-marker signals can show simultaneous expression. A detection threshold translates continuous measurements into two presence flags.1
Screen distinct allele-marker signals for simultaneous expression at a caller-defined detection threshold.
When to use Codominant Expression Screen
Use this for the following task: Screen distinct allele-marker signals for simultaneous expression at a caller-defined detection threshold.
Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
How to use Codominant Expression Screen and understand its results
- Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
- Enter firstAlleleMarkerSignal, secondAlleleMarkerSignal, minimumDetectedSignal using the field table, then run the tool.
- Read firstMarkerDetected, secondMarkerDetected, bothMarkersExpressed. Interpret flags, units, ordering and placeholder values using the rules below.
- Review any reported issue or failed check, correct the supplied values when appropriate, and verify the result in its intended context.
| Input field | Meaning | Value type and bounds | Requirement |
|---|---|---|---|
| firstAlleleMarkerSignal | First allele marker signal | number | Required |
| secondAlleleMarkerSignal | Second allele marker signal | number | Required |
| minimumDetectedSignal | Minimum detected signal | number | Required |
Supply nonnegative signals and a positive minimum in compatible units. Compare each inclusively and combine the flags.2
detected = signal ≥ minimum; bothMarkersExpressed = both detected This summarizes the declared operation. Units, indexing, inclusivity and exceptional cases are explained in the surrounding text.
| Output field | Meaning | Value type |
|---|---|---|
| firstMarkerDetected | First marker detected | boolean |
| secondMarkerDetected | Second marker detected | boolean |
| bothMarkersExpressed | Both markers expressed | boolean |
{
"input": {
"firstAlleleMarkerSignal": 4,
"secondAlleleMarkerSignal": 3,
"minimumDetectedSignal": 2
},
"output": {
"firstMarkerDetected": true,
"secondMarkerDetected": true,
"bothMarkersExpressed": true
}
}Limitations and assumptions
Marker specificity and allele identity are caller assumptions. This does not prove a complete codominant inheritance model.
The tool evaluates supplied observations or a declared model. It does not establish the biological cause of an observed pattern. Malformed requests produce input errors. A successfully evaluated request can still contain false flags, empty result lists or a result outside the supplied threshold; those outcomes have the meanings stated above.
Alternative or Complementary methods
Choose Intermediate Heterozygote Screen for this operation: Screen a measured heterozygote trait for an intermediate midpoint pattern. For a complementary task, use ABO Genotype Cross for this operation: Resolve Mendelian ABO phenotype probabilities from the supplied parental allele pairs.
Further background: Inheritance patterns.
References
-
Inheritance patterns — National Library of Medicine
-
Codominant Expression Screen — tool.io
Similar or alternative tools
- Intermediate Heterozygote Screen
Screen a measured heterozygote trait for an intermediate midpoint pattern.
- ABO Genotype Cross
Resolve Mendelian ABO phenotype probabilities from the supplied parental allele pairs.