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Lineage Division Asymmetry Size Ratio Tool

Calculate lineage division asymmetry size ratio from explicit caller-supplied inputs.

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Description

Return two lineage-size ratio conventions and a share.

Developmental biological models connect supplied dimensions, counts and growth factors under explicit geometry and sampling assumptions. A local asymmetry or inferred duration is not direct evidence of cell fate, mechanism or abnormal development.

Return two lineage-size ratio conventions and a share.

When to use this tool

Use Lineage Division Asymmetry Size Ratio when checking one supplied tissue, count or growth-model contribution.

How to use the tool and how it works

  1. Enter firstSize, secondSize. Use the units and conventions below.
  2. Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
  3. Read ratio, normalizedDifference, firstShare. Use the output convention below.

Return two lineage-size ratio conventions and a share. Require firstSize >= 0 and secondSize > 0; return first/second, (first-second)/(first+second) and first/(first+second).1

Input fieldMeaning and unitsAccepted input
firstSizeFirst SizeRequired. Finite number; minimum 0.
secondSizeSecond SizeRequired. Finite number; strictly above 0.
Output fieldInterpretationReturned shape
ratioRatioRequired. Finite number.
normalizedDifferenceNormalized DifferenceRequired. Finite number.
firstShareFirst ShareRequired. Finite number.
json
{
  "input": {
    "firstSize": 6,
    "secondSize": 4
  },
  "output": {
    "ratio": 1.5,
    "normalizedDifference": 0.2,
    "firstShare": 0.6
  }
}

Limitations and assumptions

  • Sizes share a measurement basis; the ratios do not establish asymmetric cell fate.
  • Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
  • Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Numeric signed-zero results are exported as zero.

Alternative or Complementary methods

Use appropriate biological observations and a complete validated model for developmental interpretation or experimental inference.

References

  1. Calculation and input contract: developmental-biology/lineage-division-asymmetry-size-ratio — tool.io

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