Use Carrier Frequency when you need to estimate heterozygous carrier frequency 2q(1-q) from the incidence q^2 of a recessive disease. Enter Recessive disease incidence using the definitions and units below so the result can be reproduced.

Recessive disease incidence

A finite measured or assumed value.

The published tool contract uses this rule: Estimate heterozygous carrier frequency 2q(1-q) from the incidence q^2 of a recessive disease.^[1]

Carrier frequency

The calculated carrier frequency.

The output is an estimate tied to the stated model and coefficients; it is not a direct measurement and should retain that label when reported.

Retain the original Recessive disease incidence values and their units alongside the result. Allele Frequency p is useful when you instead need to estimate dominant allele frequency p from genotype counts using p = (2*AA + Aa) / (2*total). X-Linked Male Frequency provides another view by helping you compute the frequency of affected males for an X-linked recessive trait, equal to the recessive allele frequency q under Hardy-Weinberg assumptions.

• Allele Frequency p

  Estimate dominant allele frequency p from genotype counts using p = (2*AA + Aa) / (2*total).

• X-Linked Male Frequency

  Compute the frequency of affected males for an X-linked recessive trait, equal to the recessive allele frequency q under Hardy-Weinberg assumptions.

• Genotype Frequencies

  Compute expected Hardy-Weinberg genotype frequencies p^2, 2pq, and q^2 from an allele frequency.