Use Haplotype Frequency when you need to compute haplotype frequency as haplotype count divided by two times the total number of individuals. Enter Haplotype count and Total individuals using the definitions and units below so the result can be reproduced.

Haplotype count

An integer count or setting greater than or equal to 0.

Total individuals

An integer count or setting greater than or equal to 1.

The published tool contract uses this rule: Compute haplotype frequency as haplotype count divided by two times the total number of individuals.

Haplotype frequency

The calculated haplotype frequency.

A ratio or percentage can conceal the scale of its numerator and denominator and becomes sensitive to measurement error when the denominator is small.

Retain the original Haplotype count and Total individuals values and their units alongside the result. Allele Freq From Counts is useful when you instead need to compute allele A frequency p = (2*AA + AB) / (2*(AA + AB + BB)) from genotype counts. Allele Frequency p provides another view by helping you estimate dominant allele frequency p from genotype counts using p = (2*AA + Aa) / (2*total).

• Allele Freq From Counts

  Compute allele A frequency p = (2*AA + AB) / (2*(AA + AB + BB)) from genotype counts.

• Allele Frequency p

  Estimate dominant allele frequency p from genotype counts using p = (2*AA + Aa) / (2*total).

• Carrier Frequency

  Estimate heterozygous carrier frequency 2q(1-q) from the incidence q^2 of a recessive disease.