Fold Change
Compute the fold change between condition and control means with its log2 value.
Description
Compute the fold change between condition and control means with its log2 value.
Fold Change is a focused biology tool that compute the fold change between condition and control means with its log2 value. It calculates locally from the values you enter and exposes the result without changing the source observations.1
When to use Fold Change
Use Fold Change when you need to compute the fold change between condition and control means with its log2 value. Enter Condition mean and Control mean using the definitions and units below so the result can be reproduced.
- Condition mean
- A finite measured or assumed value.
- Control mean
- A finite measured or assumed value.
How Fold Change calculates the result
The published tool contract uses this rule: Compute the fold change between condition and control means with its log2 value.
- Fold change
- The calculated fold change.
- Log2 fold change
- The calculated log2 fold change.
Limitations of Fold Change
The calculation does not propagate measurement uncertainty, sampling error, or biological and chemical variability.
Alternative or Complementary measurements
Retain the original Condition mean and Control mean values and their units alongside the result. Relative Expression Fold is useful when you instead need to convert a delta delta CT value into a relative fold change using the 2^-ddCt method. Delta Delta CT provides another view by helping you calculate the delta delta CT value by subtracting the control delta CT from the treated delta CT.
References
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Fold change — Wikipedia contributors
Similar or alternative tools
- Relative Expression Fold
Convert a delta delta CT value into a relative fold change using the 2^-ddCt method.
- Delta Delta CT
Calculate the delta delta CT value by subtracting the control delta CT from the treated delta CT.
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