Description
Preserve signed baseline-corrected research observations without censoring negative values.
Pharmacokinetic research describes concentration over time using measurement units and an explicit model. Concentration-time area, its time-weighted moment, inverse-time rate constants, clearance, and volume are related but distinct quantities. A conversion or local model term does not estimate every parameter or validate a complete study.
Preserve signed baseline-corrected research observations without censoring negative values.
When to use this tool
Use PK Baseline Corrected Negative Flag when you need this concentration-time conversion, sampling check, local integral panel, or explicitly supplied kinetic-model term.
How to use the tool and how it works
- Enter concentration, baseline, suppliedScale. Use the units and conventions below.
- Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
- Read corrected, negative. Inspect negative before interpreting the associated values.
For positive suppliedScale return corrected=(concentration-baseline)*suppliedScale and negative=(concentration<baseline).1
| Input field | Meaning and units | Accepted input |
|---|---|---|
| concentration | Concentration in the same assay unit as related concentration inputs. | Required. Finite number. |
| baseline | Baseline | Required. Finite number. |
| suppliedScale | Supplied Scale | Required. Finite number; strictly above 0. |
| Output field | Interpretation | Returned shape |
|---|---|---|
| corrected | Corrected | Required. Finite number. |
| negative | Negative | Required. Boolean. |
{
"input": {
"concentration": 2,
"baseline": 3,
"suppliedScale": 1
},
"output": {
"corrected": -1,
"negative": true
}
}Limitations and assumptions
- Concentration and baseline need one unit; the scale determines the corrected unit. Negative baseline-corrected values are retained rather than clipped, and no assay validity or imputation policy is inferred.
- Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
- Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Signed zero is exported as zero.
Alternative or Complementary methods
Use a complete study analysis when a local panel, transformation, or model factor is insufficient. Check sampling times, censoring, assay support, unit conventions, and the validity of the assumed kinetic regime.
References
Similar or alternative tools
- PK Absorption Elimination Rate Gap
Research Bateman exponential-difference factor with the equal-rate limit.
- PK Accumulation Explicit Interval Factor
Formal first-order research accumulation factor for an explicitly supplied interval.