Description
Compare caller-supplied research call confidence to an explicit boundary without phenotype or drug guidance.
Pharmacogenomic records distinguish allele labels, copy counts, reference-sequence versions, coordinate systems, and evidence about chromosome phase. A balanced count or matching token can check a record without establishing the underlying genotype. Supplied activity values and interpretation rules remain separate from a current gene-specific clinical guideline.
Compare caller-supplied research call confidence to an explicit boundary without phenotype or drug guidance.
When to use this tool
Use Allele Call Confidence Margin when you need this specific allele-token, reference-coordinate, copy-budget, or source-support check.
How to use the tool and how it works
- Enter confidence, suppliedBoundary, equalityAccepted. Use the units and conventions below.
- Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
- Read margin, acceptedUnderRule. Inspect acceptedUnderRule before interpreting the associated values.
For confidence and suppliedBoundary within zero through one return margin=confidence-suppliedBoundary and acceptedUnderRule using >= if equalityAccepted, otherwise >.1
| Input field | Meaning and units | Accepted input |
|---|---|---|
| confidence | Confidence | Required. Finite number; minimum 0; maximum 1. |
| suppliedBoundary | Supplied Boundary | Required. Finite number; minimum 0; maximum 1. |
| equalityAccepted | Equality Accepted | Required. Boolean. |
| Output field | Interpretation | Returned shape |
|---|---|---|
| margin | Signed surplus or deficit under the stated supplied rule. | Required. Finite number. |
| acceptedUnderRule | Accepted Under Rule | Required. Boolean. |
{
"input": {
"confidence": 0.9,
"suppliedBoundary": 0.8,
"equalityAccepted": true
},
"output": {
"margin": 0.09999999999999998,
"acceptedUnderRule": true
}
}Limitations and assumptions
- Confidence and the threshold are supplied. Passing this rule does not calibrate confidence, validate an assay, establish genotype accuracy, or authorize a clinical interpretation.
- Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
- Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Signed zero is exported as zero.
Alternative or Complementary methods
Use a current gene-specific nomenclature and a validated interpretation process when allele identity, phase, function, or clinical decisions matter. Verify source versions and reference coordinates before combining records.
References
Similar or alternative tools
- Genotype Call Allele Count
Count supplied allele-call tokens without calling variants, assigning phase or predicting drug response.
- Allele Source Edition Gap
Count rows with an edition different from requiredEdition, rows whose allele is absent from verifiedAlleles, and rows meeting both checks as fullySupported.