Description
Normalize a supplied response between baseline and maximum, retaining values outside the reference interval.
A pharmacodynamic model relates an exposure or occupancy measure to a response under explicitly supplied parameters. Baseline, maximum increment, half-maximal concentration, effect direction, and observation windows have distinct meanings. Evaluating one model term does not fit the curve or establish its clinical validity.
Normalize a supplied response between baseline and maximum, retaining values outside the reference interval.
When to use this tool
Use PD Baseline Normalized Effect Fraction when you need this particular response-model term, scale conversion, panel duration, or support calculation.
How to use the tool and how it works
- Enter observed, baseline, maximum. Use the units and conventions below.
- Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
- Read change, fraction, remainingFraction. Use the output convention below.
Require maximum!=baseline and return change=observed-baseline, fraction=change/(maximum-baseline), and remainingFraction=(maximum-observed)/(maximum-baseline).1
| Input field | Meaning and units | Accepted input |
|---|---|---|
| observed | Observed | Required. Finite number. |
| baseline | Supplied response level at the model's zero-effect baseline. | Required. Finite number. |
| maximum | Maximum | Required. Finite number. |
| Output field | Interpretation | Returned shape |
|---|---|---|
| change | Change | Required. Finite number. |
| fraction | Dimensionless fraction under the stated basis. | Required. Finite number. |
| remainingFraction | Remaining Fraction | Required. Finite number. |
{
"input": {
"observed": 6,
"baseline": 2,
"maximum": 10
},
"output": {
"change": 4,
"fraction": 0.5,
"remainingFraction": 0.5
}
}Limitations and assumptions
- Maximum can be below baseline and observed can lie outside their interval, so fractions outside [0,1] are retained. This is an affine normalization, not validation of a biological maximum or clinical effect.
- Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
- Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Signed zero is exported as zero.
Alternative or Complementary methods
Use a fitted and validated response model when a supplied local term is insufficient. Check exposure units, response direction, baseline, model assumptions, and observation support before comparing effects.
References
Similar or alternative tools
- PD Effect Baseline Sign Reference
Orient supplied research effect changes under an explicit sign convention without efficacy interpretation.
- Nonclinical Effect Baseline Gap
Return baselineChange=observedEffect-baselineEffect, controlAdjustedChange=baselineChange-controlEffect, and residual=controlAdjustedChange-referenceChange.