Mini Amplitude Calculator

Mean actual independently identified miniature event signed peak baseline amplitudepA, not automatic detection or absolute polarity. Actual independently matched observations/units and protocol, not diagnosis, causal mechanism, clinical decision or validated individual prediction.

Description

A miniature synaptic event amplitude can retain its polarity as peak minus baseline.

A miniature synaptic event amplitude can retain its polarity as peak minus baseline.1

This tool averages already qualified signed amplitudes in picoamperes without rectifying or detecting the events.

When to use Mini Amplitude Calculator

This tool averages already qualified signed amplitudes in picoamperes without rectifying or detecting the events.

How to use Mini Amplitude Calculator and how it works

  1. Prepare signed qualified mini peak minus baseline amplitudes pa, using the input definitions and matching units below.
  2. Enter the required fields and run Mini Amplitude Calculator.
  3. Read result.value using the units, signs and ordering explained below.
  4. Correct any rejected inputs and rerun; interpret the result within the stated model and its assumptions.
Input fieldMeaningValue typeRequirement
actualSignedQualifiedMiniPeakMinusBaselineAmplitudesPaActual Signed Qualified Mini Peak Minus Baseline Amplitudes Pa. Use the units and matching context stated in the calculation below.array of numberRequired; other constraints below

Require a nonempty list of finite signed independently qualified mini-event peak-minus-baseline amplitudes in pA. Return their arithmetic mean with polarity retained. No rectification, event detection or baseline estimation occurs.

meanAmplitudePa=sum(signedAmplitudesPa)/N

Apply the input ordering, units and branch conditions stated above.

Output fieldMeaningValue type
resultObject containing the calculated or selected fields below.object
result.valueMean signed peak-minus-baseline miniature-event amplitude in pA.number
json
{
  "input": {
    "actualSignedQualifiedMiniPeakMinusBaselineAmplitudesPa": [
      -1,
      -3
    ]
  },
  "output": {
    "result": {
      "value": -2
    }
  }
}

Limitations and assumptions

The calculation uses the supplied observations and model inputs. It does not collect measurements, select a reference population or coefficient, or establish that the model applies to the actual case. The stated branch conditions and output units remain part of the result.

All fields require explicit values. Unexpected fields, wrong types, nonfinite numbers and sparse arrays are rejected. Alignment, bounds and supported-token rules are explained above; extremely large inputs or nonfinite results can also fail. Input errors differ from successful false comparisons, unavailable-domain flags and empty match lists.

Alternative or Complementary methods

Use LTP Magnitude Calculator for a complementary operation: An LTP magnitude convention can express post-response increase relative to a matched baseline.

Use LTD Magnitude Calculator for a complementary operation: An LTD magnitude convention expresses response reduction as a positive percentage of baseline.

References

  1. Mini Amplitude Calculator — tool.io

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