Sterol Conversion Progress

Summarize lanosterol and cholesterol fractions as a conversion proxy, not flux.

Description

Sterol fractions summarize the relative amounts of lanosterol, cholesterol and other sterols.

Sterol fractions summarize the relative amounts of lanosterol, cholesterol and other sterols. A cholesterol share is a composition proxy rather than a reaction-rate measurement.^[1]

Summarize lanosterol and cholesterol fractions as a conversion proxy, not flux.

When to use Sterol Conversion Progress

Use this tool to summarize lanosterol and cholesterol fractions as a conversion proxy, not flux.

Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.

How to use Sterol Conversion Progress and understand its results

Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.
Enter lanosterol, cholesterol, otherSterols using the field table and calculation rules, then run the tool.
Read conversionProxyPercent, precursorSharePercent. The explanation below defines the units, signs, ordering and any flags or placeholder values.
If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.

Input field	Meaning	Value type; see rules below	Requirement
lanosterol	Lanosterol	number	Required
cholesterol	Cholesterol	number	Required
otherSterols	Other sterols	number	Required

Enter nonnegative compatible amounts with positive sum. Return the two percentages, including other sterols in their shared denominator.

conversionProxy%=100 cholesterol/total; precursorShare%=100 lanosterol/total

Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.

Output field	Meaning	Value type
conversionProxyPercent	Conversion proxy percent	number
precursorSharePercent	Precursor share percent	number

json

{
  "input": {
    "lanosterol": 20,
    "cholesterol": 80,
    "otherSterols": 0
  },
  "output": {
    "conversionProxyPercent": 80,
    "precursorSharePercent": 20
  }
}

Limitations and assumptions

No time course, isotope tracing or flux is inferred. Molar or other comparable amount bases must be consistent.

Numeric inputs must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors.

Alternative or Complementary methods

Use Lipid Unsaturation: Tally lipid-chain carbons and unsaturation sites. For a complementary task, use Bile Acid Hydrophobicity: Compute a weighted bile-acid hydrophobicity index from caller weights.

References

Sterol Conversion Progress — tool.io

Similar or alternative tools

Lipid Unsaturation
Tally lipid-chain carbons and unsaturation sites.
Bile Acid Hydrophobicity
Compute a weighted bile-acid hydrophobicity index from caller weights.