Ketone Redox Ratio

Compute the β-hydroxybutyrate/acetoacetate redox proxy.

Description

Ketone redox-ratio screening compares beta-hydroxybutyrate with acetoacetate on a compatible measurement basis.

Ketone redox-ratio screening compares beta-hydroxybutyrate with acetoacetate on a compatible measurement basis. The threshold is supplied rather than inferred.^[1]

Compute the β-hydroxybutyrate/acetoacetate redox proxy.

When to use Ketone Redox Ratio

Use this tool to compute the β-hydroxybutyrate/acetoacetate redox proxy.

Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.

How to use Ketone Redox Ratio and understand its results

Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.
Enter betaHydroxybutyrate, acetoacetate, minimumRedoxRatio using the field table and calculation rules, then run the tool.
Read redoxRatio, elevated. The explanation below defines the units, signs, ordering and any flags or placeholder values.
If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.

Input field	Meaning	Value type; see rules below	Requirement
betaHydroxybutyrate	Beta hydroxybutyrate	number	Required
acetoacetate	Acetoacetate	number	Required
minimumRedoxRatio	Minimum redox ratio	number	Required

Enter nonnegative BHB, positive acetoacetate and finite threshold. Return ratio and inclusive comparison.

ratio=BHB/acetoacetate; elevated=ratio≥threshold

Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.

Output field	Meaning	Value type
redoxRatio	Redox ratio	number
elevated	Elevated	boolean

json

{
  "input": {
    "betaHydroxybutyrate": 10,
    "acetoacetate": 2,
    "minimumRedoxRatio": 3
  },
  "output": {
    "redoxRatio": 5,
    "elevated": true
  }
}

Limitations and assumptions

No clinical range, pH dependence or Nernst potential is modeled.

Numeric inputs must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors. A successfully returned false flag is an evaluated outcome; its meaning is explained above.

Alternative or Complementary methods

Use NADH NAD Redox Index: Compare cellular NADH/NAD+ log10 ratio to a supplied reference. For a complementary task, use Lactate Pyruvate Ratio: Screen lactate/pyruvate redox proxy with a caller-supplied threshold.

References

Ketone Redox Ratio — tool.io

Similar or alternative tools

NADH NAD Redox Index
Compare cellular NADH/NAD+ log10 ratio to a supplied reference.
Lactate Pyruvate Ratio
Screen lactate/pyruvate redox proxy with a caller-supplied threshold.