Endocannabinoid Ratio

Compare 2-AG and anandamide abundances.

Description

An endocannabinoid ratio summarizes two supplied components, 2-AG and anandamide.

An endocannabinoid ratio summarizes two supplied components, 2-AG and anandamide. A composition percentage uses their combined denominator.1

Compare 2-AG and anandamide abundances.

When to use Endocannabinoid Ratio

Use this tool to compare 2-AG and anandamide abundances.

Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.

How to use Endocannabinoid Ratio and understand its results

  1. Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.
  2. Enter twoAg, anandamide using the field table and calculation rules, then run the tool.
  3. Read abundanceRatio, twoAgSharePercent. The explanation below defines the units, signs, ordering and any flags or placeholder values.
  4. If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.
Input fieldMeaningValue type; see rules belowRequirement
twoAgTwo agnumberRequired
anandamideAnandamidenumberRequired

Enter nonnegative 2-AG and positive anandamide on a compatible amount basis. Return ratio and 2-AG share.

ratio=twoAG/anandamide; twoAG%=100 twoAG/(twoAG+anandamide)

Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.

Output fieldMeaningValue type
abundanceRatioAbundance rationumber
twoAgSharePercentTwo ag share percentnumber
json
{
  "input": {
    "twoAg": 20,
    "anandamide": 5
  },
  "output": {
    "abundanceRatio": 4,
    "twoAgSharePercent": 80
  }
}

Limitations and assumptions

No receptor occupancy, other endocannabinoids or clinical interpretation is modeled.

Numeric inputs must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors.

Alternative or Complementary methods

Use Ketone Redox Ratio: Compute the β-hydroxybutyrate/acetoacetate redox proxy. For a complementary task, use SCFA Composition: Calculate acetate–propionate–butyrate molar percentages.

References

  1. Endocannabinoid Ratio — tool.io

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