Eicosanoid Branch

Compare caller-assigned COX and LOX eicosanoid branch signals.

Description

An eicosanoid branch summary compares summed COX-labelled and LOX-labelled signals.

An eicosanoid branch summary compares summed COX-labelled and LOX-labelled signals. The larger aggregate determines the label.^[1]

Compare caller-assigned COX and LOX eicosanoid branch signals.

When to use Eicosanoid Branch

Use this tool to compare caller-assigned COX and LOX eicosanoid branch signals.

Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.

How to use Eicosanoid Branch and understand its results

Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.
Enter coxProducts, loxProducts using the field table and calculation rules, then run the tool.
Read coxTotal, loxTotal, dominantBranch. The explanation below defines the units, signs, ordering and any flags or placeholder values.
If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.

Input field	Meaning	Value type; see rules below	Requirement
coxProducts	Cox products	list of number	Required
loxProducts	Lox products	list of number	Required

Enter nonnegative signal lists, each of which may be empty. Return branch sums and COX, LOX or tie according to exact aggregate comparison.

COX=ΣcoxSignals; LOX=ΣloxSignals

Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.

Output field	Meaning	Value type
coxTotal	Cox total	number
loxTotal	Lox total	number
dominantBranch	Dominant branch	string

json

{
  "input": {
    "coxProducts": [
      2,
      3
    ],
    "loxProducts": [
      4,
      1
    ]
  },
  "output": {
    "coxTotal": 5,
    "loxTotal": 5,
    "dominantBranch": "tie"
  }
}

Limitations and assumptions

Responses must be comparable. Signal sums do not directly measure enzyme flux or identify pathway activity.

Numeric inputs must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Lists are limited to 100,000 entries; the rules above may require smaller limits. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors.

Alternative or Complementary methods

Use SCFA Composition: Calculate acetate–propionate–butyrate molar percentages. For a complementary task, use Flux Objective Score: Evaluate a caller-supplied flux-balance objective function.

References

Eicosanoid Branch — tool.io

Similar or alternative tools

SCFA Composition
Calculate acetate–propionate–butyrate molar percentages.
Flux Objective Score
Evaluate a caller-supplied flux-balance objective function.