Bilirubin Fraction

Split bilirubin into direct and indirect fractions against a supplied threshold.

Description

Bilirubin fraction screening expresses conjugated bilirubin relative to a total.

Bilirubin fraction screening expresses conjugated bilirubin relative to a total. The indirect amount is the remainder under that two-part convention.^[1]

Split bilirubin into direct and indirect fractions against a supplied threshold.

When to use Bilirubin Fraction

Use this tool to split bilirubin into direct and indirect fractions against a supplied threshold.

Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.

How to use Bilirubin Fraction and understand its results

Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.
Enter conjugatedBilirubin, totalBilirubin, minimumDirectPercent using the field table and calculation rules, then run the tool.
Read directPercent, indirectBilirubin, directPredominant. The explanation below defines the units, signs, ordering and any flags or placeholder values.
If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.

Input field	Meaning	Value type; see rules below	Requirement
conjugatedBilirubin	Conjugated bilirubin	number	Required
totalBilirubin	Total bilirubin	number	Required
minimumDirectPercent	Minimum direct percent	number	Required

Enter positive total and conjugated amount from zero through total, with a finite percentage threshold. Return direct fraction, indirect amount and inclusive threshold flag.

direct%=100 conjugated/total; indirect=total−conjugated

Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.

Output field	Meaning	Value type
directPercent	Direct percent	number
indirectBilirubin	Indirect bilirubin	number
directPredominant	Direct predominant	boolean

json

{
  "input": {
    "conjugatedBilirubin": 1,
    "totalBilirubin": 4,
    "minimumDirectPercent": 20
  },
  "output": {
    "directPercent": 25,
    "indirectBilirubin": 3,
    "directPredominant": true
  }
}

Limitations and assumptions

No clinical reference threshold or disease classification is embedded; the supplied threshold may be signed.

Numeric inputs must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors. A successfully returned false flag is an evaluated outcome; its meaning is explained above.

Alternative or Complementary methods

Use Urea Cycle Marker Screen: Cross-check urea-cycle markers against user-selected screening cutoffs. For a complementary task, use TMAO Risk Band: Classify TMAO concentration against caller-supplied research bands, not a clinical diagnosis.

References

Bilirubin Fraction — tool.io

Similar or alternative tools

Urea Cycle Marker Screen
Cross-check urea-cycle markers against user-selected screening cutoffs.
TMAO Risk Band
Classify TMAO concentration against caller-supplied research bands, not a clinical diagnosis.