Anaplerosis Flux Split
Partition two measured anaplerosis-associated fluxes by caller-defined branches.
Description
Anaplerotic flux splitting expresses two supplied branch contributions as percentages of their sum.
Anaplerotic flux splitting expresses two supplied branch contributions as percentages of their sum. The labels describe the provided branches rather than inferred reaction mechanisms.1
Partition two measured anaplerosis-associated fluxes by caller-defined branches.
When to use Anaplerosis Flux Split
Use this tool to partition two measured anaplerosis-associated fluxes by caller-defined branches.
Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.
How to use Anaplerosis Flux Split and understand its results
- Prepare the measured profile, formula counts, upstream model outputs or caller-defined reference criteria requested. Keep paired entries aligned and units, sample basis and preprocessing consistent.
- Enter pyruvateCarboxylaseFlux, pepckFlux using the field table and calculation rules, then run the tool.
- Read totalFlux, carboxylaseSharePercent, pepckSharePercent. The explanation below defines the units, signs, ordering and any flags or placeholder values.
- If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.
| Input field | Meaning | Value type; see rules below | Requirement |
|---|---|---|---|
| pyruvateCarboxylaseFlux | Pyruvate carboxylase flux | number | Required |
| pepckFlux | Pepck flux | number | Required |
Enter nonnegative contributions with positive total. Return sum and the two shares.
total=branchA+branchB; share%=100 branch/total Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.
| Output field | Meaning | Value type |
|---|---|---|
| totalFlux | Total flux | number |
| carboxylaseSharePercent | Carboxylase share percent | number |
| pepckSharePercent | Pepck share percent | number |
{
"input": {
"pyruvateCarboxylaseFlux": 30,
"pepckFlux": 70
},
"output": {
"totalFlux": 100,
"carboxylaseSharePercent": 30,
"pepckSharePercent": 70
}
}Limitations and assumptions
No flux estimation, isotope model or network balance is performed.
Numeric inputs must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors.
Alternative or Complementary methods
Use Stoichiometric Flux Balance: Check S·v steady-state residuals against a supplied flux-balance tolerance. For a complementary task, use Flux Objective Score: Evaluate a caller-supplied flux-balance objective function.
References
-
Anaplerosis Flux Split — tool.io
Similar or alternative tools
- Stoichiometric Flux Balance
Check S·v steady-state residuals against a supplied flux-balance tolerance.
- Flux Objective Score
Evaluate a caller-supplied flux-balance objective function.