Description
Calculate focal fold change relative to a supplied reference competition fold change.
Evolutionary summaries depend on sampled sequences/populations, reference states, ploidy, time units and stochastic assumptions. A mixture expectation differs from a drift simulation, and a callable-allele denominator differs from an individual count. Labels and local tree conditions do not reconstruct ancestry or establish a biological mechanism.
Calculate focal fold change relative to a supplied reference competition fold change.
When to use this tool
Use Fitness Assay Reference Competition Ratio when checking the stated evolutionary record, reference, expectation or scale convention.
How to use the tool and how it works
- Enter focalFoldChange, referenceFoldChange. Use the units and conventions below.
- Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
- Read relativeFoldChange. Use the output convention below.
Require focalFoldChange>=0 and referenceFoldChange>0. Return focal/reference relativeFoldChange.1
| Input field | Meaning and units | Accepted input |
|---|---|---|
| focalFoldChange | Focal Fold Change | Required. Finite number; minimum 0. |
| referenceFoldChange | Reference Fold Change | Required. Finite number; strictly above 0. |
| Output field | Interpretation | Returned shape |
|---|---|---|
| relativeFoldChange | Relative Fold Change | Required. Finite number. |
{
"input": {
"focalFoldChange": 4,
"referenceFoldChange": 2
},
"output": {
"relativeFoldChange": 2
}
}Limitations and assumptions
- Both changes need the same assay interval and reporting basis; the ratio does not establish an absolute fitness, selection coefficient or biological mechanism.
- Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
- Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Numeric signed-zero results are exported as zero.
Alternative or Complementary methods
Use verified samples/references and appropriate complete phylogenetic, population-genetic or statistical models for actual biological inference and uncertainty.
References
Similar or alternative tools
- Population Transfer Dilution Count
Calculate expected transferred and remaining population counts under a supplied transfer fraction.
- Migration Drift Generation Expectation
Calculate an expected allele frequency after deterministic migration mixing.