Methylation M Value

Convert a methylation beta fraction into a base-two logit M-value.

Description

M-values put beta fractions on a log-odds scale.

M-values put beta fractions on a log-odds scale.^[1]

Convert a methylation beta fraction into a base-two logit M-value.

When to use Methylation M Value

Use this tool to convert a methylation beta fraction into a base-two logit M-value.

Prepare the already measured signals, counts, coordinates, fitted coefficients or sequence strings requested. Keep assay definitions, units, aligned lists and caller-selected thresholds consistent.

How to use Methylation M Value and understand its results

Prepare the already measured signals, counts, coordinates, fitted coefficients or sequence strings requested. Keep assay definitions, units, aligned lists and caller-selected thresholds consistent.
Enter beta using the field table and calculation rules, then run the tool.
Read mValue. The explanation below defines the units, signs, ordering and any flags or placeholder values.
If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.

Input field	Meaning	Value type; see rules below	Requirement
beta	Beta	number	Required

Enter beta strictly between zero and one; return log2 odds. Endpoints are rejected.

M=log2(beta/(1−beta))

Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.

Output field	Meaning	Value type
mValue	M value	number

json

{
  "input": {
    "beta": 0.5
  },
  "output": {
    "mValue": 0
  }
}

Limitations and assumptions

No probe offset, normalization or differential test is applied.

Numeric inputs, where present, must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors.

Alternative or Complementary methods

Use Methylation Beta From M: Invert a base-two methylation M-value into a beta fraction. For a complementary task, use Single-CpG Methylation: Calculate single-CpG methylation after background correction.

References

Methylation M Value — tool.io

Similar or alternative tools

Methylation Beta From M
Invert a base-two methylation M-value into a beta fraction.
Single-CpG Methylation
Calculate single-CpG methylation after background correction.