Methylation Beta From M
Invert a base-two methylation M-value into a beta fraction.
Description
Beta is the inverse log-odds form of a methylation M-value.
Beta is the inverse log-odds form of a methylation M-value.1
Invert a base-two methylation M-value into a beta fraction.
When to use Methylation Beta From M
Use this tool to invert a base-two methylation M-value into a beta fraction.
Prepare the already measured signals, counts, coordinates, fitted coefficients or sequence strings requested. Keep assay definitions, units, aligned lists and caller-selected thresholds consistent.
How to use Methylation Beta From M and understand its results
- Prepare the already measured signals, counts, coordinates, fitted coefficients or sequence strings requested. Keep assay definitions, units, aligned lists and caller-selected thresholds consistent.
- Enter mValue using the field table and calculation rules, then run the tool.
- Read beta. The explanation below defines the units, signs, ordering and any flags or placeholder values.
- If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.
| Input field | Meaning | Value type; see rules below | Requirement |
|---|---|---|---|
| mValue | M value | number | Required |
Enter finite signed M and return beta; extreme magnitudes can saturate to zero or one.
beta=1/(1+2^(−M)) Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.
| Output field | Meaning | Value type |
|---|---|---|
| beta | Beta | number |
{
"input": {
"mValue": 0
},
"output": {
"beta": 0.5
}
}Limitations and assumptions
No signal calibration or biological information is added.
Numeric inputs, where present, must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors.
Alternative or Complementary methods
Use Methylation M Value: Convert a methylation beta fraction into a base-two logit M-value. For a complementary task, use Single-CpG Methylation: Calculate single-CpG methylation after background correction.
References
-
Methylation Beta From M — tool.io
Similar or alternative tools
- Methylation M Value
Convert a methylation beta fraction into a base-two logit M-value.
- Single-CpG Methylation
Calculate single-CpG methylation after background correction.