Epigenetic Age Residual

Calculate and classify epigenetic age acceleration.

Description

A simple epigenetic-age residual differs from an age-adjusted regression residual.

A simple epigenetic-age residual differs from an age-adjusted regression residual.^[1]

Calculate and classify epigenetic age acceleration.

When to use Epigenetic Age Residual

Use this tool to calculate and classify epigenetic age acceleration.

Prepare the already measured signals, counts, coordinates, fitted coefficients or sequence strings requested. Keep assay definitions, units, aligned lists and caller-selected thresholds consistent.

How to use Epigenetic Age Residual and understand its results

Prepare the already measured signals, counts, coordinates, fitted coefficients or sequence strings requested. Keep assay definitions, units, aligned lists and caller-selected thresholds consistent.
Enter epigeneticAgeYears, chronologicalAgeYears, residualStdDevYears using the field table and calculation rules, then run the tool.
Read ageResidualYears, standardizedResidual, class. The explanation below defines the units, signs, ordering and any flags or placeholder values.
If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.

Input field	Meaning	Value type; see rules below	Requirement
epigeneticAgeYears	Epigenetic age	number; minimum: 0	Required
chronologicalAgeYears	Chronological age	number; minimum: 0	Required
residualStdDevYears	Residual standard deviation	number; minimum: 0	Required

Enter nonnegative ages and positive SD. Return residual/standardized score; >1 accelerated, <−1 decelerated, otherwise typical including endpoints.

residual=epigenetic−chronological; standardized=residual/referenceSD

Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.

Output field	Meaning	Value type
ageResidualYears	Age residual	number
standardizedResidual	Standardized residual	number
class	Acceleration class	string; one of "decelerated", "typical", "accelerated"

json

{
  "input": {
    "epigeneticAgeYears": 60,
    "chronologicalAgeYears": 50,
    "residualStdDevYears": 5
  },
  "output": {
    "ageResidualYears": 10,
    "standardizedResidual": 2,
    "class": "accelerated"
  }
}

Limitations and assumptions

No methylation clock, regression or clinical diagnosis is fitted.

Numeric inputs, where present, must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors.

Alternative or Complementary methods

Use GrimAge Risk Score: Score a caller-calibrated methylation mortality-risk composite; no built-in clinical coefficients. For a complementary task, use DunedinPACE Ratio: Compare a measured epigenetic pace of aging to an injected reference pace.

References

Epigenetic Age Residual — tool.io

Similar or alternative tools

GrimAge Risk Score
Score a caller-calibrated methylation mortality-risk composite; no built-in clinical coefficients.
DunedinPACE Ratio
Compare a measured epigenetic pace of aging to an injected reference pace.