DunedinPACE Ratio

Compare a measured epigenetic pace of aging to an injected reference pace.

Description

A biological-change ratio is a supplied pace measure.

A biological-change ratio is a supplied pace measure. It differs from the published trained DunedinPACE methylation algorithm.^{[1, 2]}

Compare a measured epigenetic pace of aging to an injected reference pace.

When to use DunedinPACE Ratio

Use this tool to compare a measured epigenetic pace of aging to an injected reference pace.

Prepare the already measured signals, counts, coordinates, fitted coefficients or sequence strings requested. Keep assay definitions, units, aligned lists and caller-selected thresholds consistent.

How to use DunedinPACE Ratio and understand its results

Prepare the already measured signals, counts, coordinates, fitted coefficients or sequence strings requested. Keep assay definitions, units, aligned lists and caller-selected thresholds consistent.
Enter biologicalYearsElapsed, chronologicalYearsElapsed, referencePace using the field table and calculation rules, then run the tool.
Read paceRatio, relativePace, fasterThanReference. The explanation below defines the units, signs, ordering and any flags or placeholder values.
If the tool reports an input issue, correct the values and run it again. Apply the stated assumptions when interpreting a successfully returned result.

Input field	Meaning	Value type; see rules below	Requirement
biologicalYearsElapsed	Biological years elapsed	number	Required
chronologicalYearsElapsed	Chronological years elapsed	number	Required
referencePace	Reference pace	number	Required

Enter nonnegative biological change and positive chronological change/reference. Return ratios and strict pace>reference flag.

pace=biologicalChange/chronologicalChange; relative=pace/reference

Units, indexing, boundary conditions and exceptional cases are defined in the calculation rules above.

Output field	Meaning	Value type
paceRatio	Pace ratio	number
relativePace	Relative pace	number
fasterThanReference	Faster than reference	boolean

json

{
  "input": {
    "biologicalYearsElapsed": 12,
    "chronologicalYearsElapsed": 10,
    "referencePace": 1
  },
  "output": {
    "paceRatio": 1.2,
    "relativePace": 1.2,
    "fasterThanReference": true
  }
}

Limitations and assumptions

No trained coefficients, methylation data or clinical aging assessment is provided.

Numeric inputs, where present, must be finite. Follow the calculation-specific rules for overflow, underflow and exceptional cases. Missing required fields, extra fields, wrong value types and violations of the calculation rules are input errors. A successfully returned false flag is an evaluated outcome; its meaning is explained above.

Alternative or Complementary methods

Use Epigenetic Age Residual: Calculate and classify epigenetic age acceleration. For a complementary task, use GrimAge Risk Score: Score a caller-calibrated methylation mortality-risk composite; no built-in clinical coefficients.

Further background: DunedinPACE, a DNA methylation biomarker of the pace of aging.

References

DunedinPACE Ratio — tool.io
DunedinPACE, a DNA methylation biomarker of the pace of aging — Belsky and colleagues

Similar or alternative tools

Epigenetic Age Residual
Calculate and classify epigenetic age acceleration.
GrimAge Risk Score
Score a caller-calibrated methylation mortality-risk composite; no built-in clinical coefficients.