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Developmental Expression Domain Width Share Tool

Calculate developmental expression domain width share from explicit caller-supplied inputs.

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Description

Return expression-domain width relative to an enclosing axis.

Morphogen models distinguish amount flow, concentration and spatial decay. A steady exponential profile or local flux balance requires explicit geometry, reaction assumptions and compatible units; it is not a fitted mechanism.

Return expression-domain width relative to an enclosing axis.

When to use this tool

Use Developmental Expression Domain Width Share when checking a supplied morphogen-domain or balance term.

How to use the tool and how it works

  1. Enter domainStart, domainEnd, axisStart, axisEnd. Use the units and conventions below.
  2. Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
  3. Read width, axisFraction. Use the output convention below.

Return expression-domain width relative to an enclosing axis. Require axisEnd > axisStart and axisStart <= domainStart <= domainEnd <= axisEnd; axisFraction = domain width/axis length.1

Input fieldMeaning and unitsAccepted input
domainStartDomain StartRequired. Finite number.
domainEndDomain EndRequired. Finite number.
axisStartAxis StartRequired. Finite number.
axisEndAxis EndRequired. Finite number.
Output fieldInterpretationReturned shape
widthExtent on the stated coordinate or temporal basis.Required. Finite number.
axisFractionAxis FractionRequired. Finite number.
json
{
  "input": {
    "domainStart": 2,
    "domainEnd": 6,
    "axisStart": 0,
    "axisEnd": 10
  },
  "output": {
    "width": 4,
    "axisFraction": 0.4
  }
}

Limitations and assumptions

  • Zero domain width is accepted; boundaries are supplied rather than detected from expression data.
  • Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
  • Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Numeric signed-zero results are exported as zero.

Alternative or Complementary methods

Use suitable concentration measurements, boundary conditions and a full transport/reaction model when inferring developmental mechanisms.

References

  1. Calculation and input contract: developmental-biology/developmental-expression-domain-width-share — tool.io

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