Observed Heterozygosity
Compute observed heterozygosity as the fraction of individuals that are heterozygous.
Description
Compute observed heterozygosity as the fraction of individuals that are heterozygous.
Observed Heterozygosity is a focused biology tool that compute observed heterozygosity as the fraction of individuals that are heterozygous. It calculates locally from the values you enter and exposes the result without changing the source observations.1
When to use Observed Heterozygosity
Use Observed Heterozygosity when you need to compute observed heterozygosity as the fraction of individuals that are heterozygous. Enter Heterozygotes and Total individuals using the definitions and units below so the result can be reproduced.
- Heterozygotes
- An integer count or setting greater than or equal to 0.
- Total individuals
- An integer count or setting greater than or equal to 1.
How Observed Heterozygosity calculates the result
The published tool contract uses this rule: Compute observed heterozygosity as the fraction of individuals that are heterozygous.
- Observed heterozygosity
- The calculated observed heterozygosity.
Limitations of Observed Heterozygosity
A ratio or percentage can conceal the scale of its numerator and denominator and becomes sensitive to measurement error when the denominator is small.
Alternative or Complementary measurements
Retain the original Heterozygotes and Total individuals values and their units alongside the result. Expected Heterozygosity is useful when you instead need to compute expected heterozygosity he = 1 - (p^2 + q^2) at a two-allele locus. Allele Count Total provides another view by helping you count total allele copies at a diploid locus as twice the number of individuals.
References
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Zygosity — Wikipedia contributors
Similar or alternative tools
- Expected Heterozygosity
Compute expected heterozygosity he = 1 - (p^2 + q^2) at a two-allele locus.
- Allele Count Total
Count total allele copies at a diploid locus as twice the number of individuals.
- Coancestry Coefficient
Compute the coancestry or kinship phi of two individuals as half of their additive relationship coefficient.