Tubular Secretion Calculator
Declared renal mass balance excretion=filtration+secretion−reabsorption; secretion residual from independently resolved compatible rates. Negative discrepancy retained, not infer tubular transport from plasma alone or clinical renal function.
Description
Renal mass balance separates filtration, secretion and reabsorption contributions to removal.
Renal mass balance separates filtration, secretion and reabsorption contributions to removal.1
A residual calculation requires all rates to refer to the same substance, pool and time basis.
When to use Tubular Secretion Calculator
Use this tool to calculate or review the supplied observations under the stated rules. Establish the chemical, exposure route, endpoint, measurement basis and independently applicable assay or assessment reference.
How to use Tubular Secretion Calculator and understand its results
- Establish the chemical, exposure route, endpoint, measurement basis and independently applicable assay or assessment reference.
- Enter actualTotalRenalRemovalMassPerTime, independentlyAssessedFilteredRemovalMassPerTime, independentlyAssessedReabsorbedMassPerTime, using the field meanings and rules below, then run the tool.
- Read result.conditionalNetSecretedMassPerTime. Use the units and subtraction order below to interpret each value; retain negative differences where returned.
- Correct any reported input issue and run again. Before using a successful result, check the stated units, signs, reference scope and observation coverage.
| Input field | Meaning | Value type | Requirement |
|---|---|---|---|
| actualTotalRenalRemovalMassPerTime | Actual total renal removal mass per time | number | Required |
| independentlyAssessedFilteredRemovalMassPerTime | Independently assessed filtered removal mass per time | number | Required |
| independentlyAssessedReabsorbedMassPerTime | Independently assessed reabsorbed mass per time | number | Required |
Require nonnegative independently measured excretion, filtration and reabsorption rates in compatible mass-per-time units. Rearrange the declared renal balance for secretion. A negative balance is returned unchanged and requires review of the measurements and model assumptions.
signedSecretionRate=excretionRate−filtrationRate+reabsorptionRate Use the matching field units and the exact boundary, ordering and reference rules above.
| Output field | Meaning | Value type |
|---|---|---|
| result | Qualified observed calculation or explicit reference | object |
| result.conditionalNetSecretedMassPerTime | Excretion minus filtration plus reabsorption; negative balances are retained. | number |
{
"input": {
"actualTotalRenalRemovalMassPerTime": 10,
"independentlyAssessedFilteredRemovalMassPerTime": 4,
"independentlyAssessedReabsorbedMassPerTime": 2
},
"output": {
"result": {
"conditionalNetSecretedMassPerTime": 8
}
}
}Limitations and assumptions
Chemical identity, route, assay, exposure basis and reference applicability are caller-established. The output supplies no causal conclusion, universal toxicity threshold or authoritative regulatory determination.
Missing required fields, unknown fields, wrong types and violated rules return input issues. Numeric values and outputs must be finite. Extremely large composite outputs are rejected.
Alternative or Complementary methods
For a related step, use Renal Clearance Calculator: Renal clearance relates urinary mass removal per time to matched plasma concentration. For a complementary comparison, use Clearance Calculator: Clearance relates independently attributed removal mass per time to matched concentration.
References
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Tubular Secretion Calculator — tool.io
Similar or alternative tools
- Renal Clearance Calculator
Renal clearance relates urinary mass removal per time to matched plasma concentration.
- Clearance Calculator
Clearance relates independently attributed removal mass per time to matched concentration.