Skin Irritation PII Calculator

Declared PIImean independently coded erythema+edema per actual same site/time0–4each. Unknowns retained; actual test protocol, averaging weights and clinical/animal interpretation external, no automatic hazard category or procedures.

Description

A primary irritation index can summarize independently coded erythema and edema observations.

A primary irritation index can summarize independently coded erythema and edema observations.^[1]

Sites, times, scoring rubric and averaging convention must be matched before combining those scores.

When to use Skin Irritation PII Calculator

Use this tool to calculate or review the supplied observations under the stated rules. Establish the chemical, exposure route, endpoint, measurement basis and independently applicable assay or assessment reference.

How to use Skin Irritation PII Calculator and understand its results

Establish the chemical, exposure route, endpoint, measurement basis and independently applicable assay or assessment reference.
Enter independentlyCodedErythemaScores, independentlyCodedEdemaScores, actualObservationKnownFlags, using the field meanings and rules below, then run the tool.
Read result.observedKnownPrimaryIrritationIndex, result.unknownObservationIndices. Use the units and subtraction order below to interpret each value; retain negative differences where returned.
Correct any reported input issue and run again. Before using a successful result, check the stated units, signs, reference scope and observation coverage.

Input field	Meaning	Value type	Requirement
independentlyCodedErythemaScores	Independently coded erythema scores	list of number	Required
independentlyCodedEdemaScores	Independently coded edema scores	list of number	Required
actualObservationKnownFlags	Actual observation known flags; binary 1 means the matched observation is known, 0 means unknown	list of number	Required

Supply nonempty aligned erythema and edema integer codes from 0 through 4 and binary known flags. All codes are validated, including unknown-row placeholders. Average the sums of erythema plus edema over known rows only. At least one row must be known; return zero-based unknown indices separately.

primaryIrritationIndex=mean(erythema_i+edema_i where known_i=1)

Use the matching field units and the exact boundary, ordering and reference rules above.

Output field	Meaning	Value type
result	Qualified observed calculation or explicit reference	object
result.observedKnownPrimaryIrritationIndex	Mean of erythema-plus-edema codes over known observations only.	number
result.unknownObservationIndices	Zero-based observations excluded from the known-row index mean.	list

json

{
  "input": {
    "independentlyCodedErythemaScores": [
      1,
      2
    ],
    "independentlyCodedEdemaScores": [
      1,
      0
    ],
    "actualObservationKnownFlags": [
      1,
      1
    ]
  },
  "output": {
    "result": {
      "observedKnownPrimaryIrritationIndex": 2,
      "unknownObservationIndices": []
    }
  }
}

Limitations and assumptions

Chemical identity, route, assay, exposure basis and reference applicability are caller-established. The output supplies no causal conclusion, universal toxicity threshold or authoritative regulatory determination.

Missing required fields, unknown fields, wrong types and violated rules return input issues. Numeric values and outputs must be finite. Lists and matrices must be dense, without missing cells. Numeric lists allow at most 10000 entries, subject to the narrower lengths and code rules above. Extremely large composite outputs are rejected.

Alternative or Complementary methods

For a related step, use Skin Corrosion Category Lookup: Skin-corrosion categories belong to an adopted classification framework and applicable evidence. For a complementary comparison, use Eye Irritation Draize Calculator: Draize ocular assessment uses protocol-specific domains, observations and weighting.

References

Skin Irritation PII Calculator — tool.io

Similar or alternative tools

Skin Corrosion Category Lookup
Skin-corrosion categories belong to an adopted classification framework and applicable evidence.
Eye Irritation Draize Calculator
Draize ocular assessment uses protocol-specific domains, observations and weighting.