Dermal Absorption Dose

Integrate supplied dermal contact loadings, distinct contact areas and absorbed fractions into mass-normalized dose; overlapping contact areas and time integration must be resolved externally.

Description

Sum absorbed dermal contact masses and divide by body mass to obtain an event dose in mg/kg.

Dermal exposure distinguishes material contacting the skin from the portion absorbed. Surface loading expresses mass per area, while an absorption fraction represents the assumed proportion crossing the skin under a specified scenario. Those inputs need an evidence-based exposure definition.^[1]

This tool treats each entry as a contact segment: loading in mg/cm², area in cm², and a fraction from zero to one. It reports absorbed mass for each segment in mg and their total divided by body mass in kg. The resulting mg/kg is an amount per body mass, without an automatic daily time basis.

When to use Dermal Absorption Dose

Use it for a contact-event worksheet with specified surface loading and absorption, or compare contributions from different contact regions or materials.

How to use Dermal Absorption Dose and understand its results

Enter aligned, nonempty contactMassMgPerSquareCm, contactAreasSquareCm, and absorbedFractions arrays. Loading and area may be zero; fractions must be between zero and one.
Enter positive bodyMassKg and ensure each segment represents a separate intended contribution without double counting.
Run the calculation and inspect segmentAbsorbedMassMg and absorbedDoseMgPerKg. Add an explicit exposure-duration basis separately if needed.

absorbed mass_i = loading_i × area_i × fraction_i; absorbed dose = Σ absorbed mass_i / body mass

Fractions multiply contacting mass; the calculator does not infer absorption from a permeability coefficient.

json

{
  "input": {
    "contactMassMgPerSquareCm": [
      0.1,
      0.2
    ],
    "contactAreasSquareCm": [
      100,
      50
    ],
    "absorbedFractions": [
      0.1,
      0.2
    ],
    "bodyMassKg": 50
  },
  "output": {
    "segmentAbsorbedMassMg": [
      1,
      2
    ],
    "absorbedDoseMgPerKg": 0.06
  }
}

Zero loading, area, or absorption fraction yields zero contribution. Fraction one absorbs all of the supplied contacting mass. Fraction values above one, negative values, zero body mass, and mismatched arrays are rejected.

Limitations and assumptions

No time-dependent diffusion, washing, occlusion, skin condition, formulation, or permeability fitting is modeled. Enter loading of the chemical of interest rather than bulk material unless appropriately converted.

The result does not establish health risk. Any comparison with a daily reference dose requires compatible time and absorbed-versus-administered dose definitions.

Alternative or Complementary methods

Estimate permeability through a suitable calibrated model when that is the missing parameter. A route aggregation tool can combine separately prepared route amounts after checking that they share an exposure basis.

References

Exposure Assessment Tools by Routes: Dermal — U.S. Environmental Protection Agency

Similar or alternative tools

Skin Permeability Coefficient
Calculate permeability from supplied properties and calibration coefficients.
Aggregate Route Dose
Combine supplied route amounts and absorption fractions.