Description
Normalize one supplied nonclinical model residual without selecting an error model.
Pharmacokinetic research describes concentration over time using measurement units and an explicit model. Concentration-time area, its time-weighted moment, inverse-time rate constants, clearance, and volume are related but distinct quantities. A conversion or local model term does not estimate every parameter or validate a complete study.
Normalize one supplied nonclinical model residual without selecting an error model.
When to use this tool
Use PK Residual Normalization Term when you need this concentration-time conversion, sampling check, local integral panel, or explicitly supplied kinetic-model term.
How to use the tool and how it works
- Enter observed, predicted, suppliedScale. Use the units and conventions below.
- Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
- Read residual, normalizedResidual. Use the output convention below.
For positive suppliedScale return residual=observed-predicted and normalizedResidual=residual/suppliedScale.1
| Input field | Meaning and units | Accepted input |
|---|---|---|
| observed | Observed | Required. Finite number. |
| predicted | Predicted | Required. Finite number. |
| suppliedScale | Supplied Scale | Required. Finite number; strictly above 0. |
| Output field | Interpretation | Returned shape |
|---|---|---|
| residual | Signed observed-minus-implied discrepancy under the stated formula. | Required. Finite number. |
| normalizedResidual | Normalized Residual | Required. Finite number. |
{
"input": {
"observed": 12,
"predicted": 10,
"suppliedScale": 2
},
"output": {
"residual": 2,
"normalizedResidual": 1
}
}Limitations and assumptions
- Scale must be compatible with the concentration residual for a dimensionless result. No variance estimate, weighting model, normality check, or pharmacokinetic fit is performed.
- Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
- Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Signed zero is exported as zero.
Alternative or Complementary methods
Use a complete study analysis when a local panel, transformation, or model factor is insufficient. Check sampling times, censoring, assay support, unit conventions, and the validity of the assumed kinetic regime.
References
Similar or alternative tools
- PK Research Compartment Mass Balance Residual
For nonnegative compartment amounts return expectedClosing=opening+input-eliminated-transferredOut+transferredIn, residual=measuredClosing-expectedClosing, and totalOut=eliminated+transferredOut.
- Nonclinical Terminal Slope Point Residual
Compare one nonclinical point to a supplied log-linear curve without fitting a terminal phase or recommending doses.