Description
Calculate the quantified share of a supplied concentration-duration integral within a selected window.
Pharmacokinetic research describes concentration over time using measurement units and an explicit model. Concentration-time area, its time-weighted moment, inverse-time rate constants, clearance, and volume are related but distinct quantities. A conversion or local model term does not estimate every parameter or validate a complete study.
Calculate the quantified share of a supplied concentration-duration integral within a selected window.
When to use this tool
Use Concentration Support Window Share when you need this concentration-time conversion, sampling check, local integral panel, or explicitly supplied kinetic-model term.
How to use the tool and how it works
- Enter concentrations, durations, inWindow, quantified. Keep parallel arrays aligned. Use the units and conventions below.
- Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
- Read windowIntegral, supportedIntegral, share, defined. Inspect defined before interpreting the associated values.
Require aligned concentrations, durations, inWindow, and quantified arrays with nonnegative concentrations and durations. Sum concentration*duration for in-window rows into windowIntegral, and rows also quantified into supportedIntegral; return share=supportedIntegral/windowIntegral when positive, otherwise zero with defined=false.1
| Input field | Meaning and units | Accepted input |
|---|---|---|
| concentrations | Concentrations on one compatible assay scale. | Required. Array of finite number; maximum items 256. |
| durations | Durations | Required. Array of finite number; maximum items 256. |
| inWindow | In Window | Required. Array of boolean; maximum items 256. |
| quantified | Quantified | Required. Array of boolean; maximum items 256. |
| Output field | Interpretation | Returned shape |
|---|---|---|
| windowIntegral | Window Integral | Required. Finite number. |
| supportedIntegral | Supported Integral | Required. Finite number. |
| share | Dimensionless share under the stated base; not a percentage numeral. | Required. Finite number. |
| defined | Whether the associated ratio is defined; inspect before using a zero placeholder. | Required. Boolean. |
{
"input": {
"concentrations": [
2,
3,
5
],
"durations": [
1,
2,
1
],
"inWindow": [
true,
true,
false
],
"quantified": [
true,
false,
true
]
},
"output": {
"windowIntegral": 8,
"supportedIntegral": 2,
"share": 0.25,
"defined": true
}
}Limitations and assumptions
- This is a rectangular contribution-weighted support share. Durations and flags are supplied; overlaps, sampling gaps, censoring, assay validity, and a full AUC integration rule are not inferred.
- Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
- Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Signed zero is exported as zero.
Alternative or Complementary methods
Use a complete study analysis when a local panel, transformation, or model factor is insufficient. Check sampling times, censoring, assay support, unit conventions, and the validity of the assumed kinetic regime.
References
Similar or alternative tools
- Concentration Time Unit Factor
Convert an already supplied nonclinical concentration-time quantity using explicit compatible unit factors.
- Nonclinical Concentration Logstep
Compare explicitly supplied nonclinical concentration observations without dosing or extrapolated patient predictions.