HRP2 Negative Test Discordance
Flag discordance between negative HRP2 assay results and independent parasite evidence; not a diagnosis.
Description
A negative HRP2 result can disagree with independent parasite evidence.
A negative HRP2 result can disagree with independent parasite evidence. Such discordance and confirmed gene-deletion evidence are different facts.
The tool returns discordantNegative (discordant negative); deletionAssociatedConcern (deletion associated concern). Input measurements and model parameters are supplied by the caller; the tool computes the stated summary rather than acquiring those measurements.
When to use HRP2 Negative Test Discordance
Use HRP2 Negative Test Discordance when you already have hrp2DeletionConfirmed, hrp2RdtNegative, independentParasiteEvidence and want discordantNegative, deletionAssociatedConcern. This is useful for checking a supplied calculation, documenting a measurement convention, or comparing observations prepared on the same basis.
How to use HRP2 Negative Test Discordance and understand its results
- Enter hrp2DeletionConfirmed, hrp2RdtNegative, independentParasiteEvidence using the field table below. Match the units, ordering and data boundaries described in the calculation.
- Run the tool after checking the stated bounds and matching paired observations or categories. A malformed request gives a tool error rather than a usable measurement.
- Read discordantNegative, deletionAssociatedConcern. Use the calculation and interpretation below to distinguish amounts, ratios, signs and decision flags where applicable.
- Review the supplied parameters and assumptions before using the result in a report or comparing it with another observation.
| Input field | Meaning | Value type and bounds | Requirement |
|---|---|---|---|
| hrp2DeletionConfirmed | Hrp 2 deletion confirmed | boolean | Required |
| hrp2RdtNegative | Hrp 2 rdt negative | boolean | Required |
| independentParasiteEvidence | Independent parasite evidence | boolean | Required |
Combine the supplied booleans directly; gene-deletion concern requires both discordance and confirmation.
discordant = HRP2Negative AND independentEvidence; deletionConcern = discordant AND confirmedDeletion The symbols refer to the supplied quantities or generated values described above; unit conversions and comparison boundaries follow the stated implementation.
{
"input": {
"hrp2DeletionConfirmed": true,
"hrp2RdtNegative": true,
"independentParasiteEvidence": true
},
"output": {
"discordantNegative": true,
"deletionAssociatedConcern": true
}
}Limitations and assumptions
The tool neither diagnoses malaria nor confirms a deletion from a negative rapid test. Evidence quality and alternative explanations need separate assessment.
Numerical inputs must be finite. The tool checks its declared input shape and calculation constraints; those checks do not verify the quality, calibration or representativeness of the supplied observations.
Alternative or Complementary methods
K13 Marker Match: Match observed K13 marker annotations against a caller-supplied concern set; no embedded resistance catalog. Multiplex Target Decode: Decode multiplex target detections while preserving the supplied assay-control validity flag.
Methodological background: Malaria: artemisinin partial resistance.1
References
-
Malaria: artemisinin partial resistance — World Health Organization
Similar or alternative tools
- K13 Marker Match
Match observed K13 marker annotations against a caller-supplied concern set; no embedded resistance catalog.
- Multiplex Target Decode
Decode multiplex target detections while preserving the supplied assay-control validity flag.