Osteopathic Study Crossover Period Imbalance Tool

Description

Descriptive supplied crossover contrasts without causal or carryover identification.

Evidence review distinguishes reporting completeness, source identity, timing, comparator descriptions, and the validity of a clinical claim. Matching metadata or calculating an interval cannot establish study quality or treatment efficacy. Measurement and protocol conventions need to remain explicit before records are compared.

Descriptive supplied crossover contrasts without causal or carryover identification.

When to use this tool

Use Osteopathic Study Crossover Period Imbalance when you need this specific evidence-record, measurement, interval, comparator, or protocol check.

How to use the tool and how it works

Enter firstActive, firstControl, secondActive, secondControl. Use the units and conventions below.
Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
Read firstContrast, secondContrast, periodDifference, sequenceImbalance. Use the output convention below.

Return firstContrast=firstActive-firstControl, secondContrast=secondActive-secondControl, periodDifference=(secondActive+secondControl-firstActive-firstControl)/2, and sequenceImbalance=firstActive+secondControl-firstControl-secondActive.^[1]

Input field	Meaning and units	Accepted input
firstActive	First Active	Required. Finite number.
firstControl	First Control	Required. Finite number.
secondActive	Second Active	Required. Finite number.
secondControl	Second Control	Required. Finite number.

Output field	Interpretation	Returned shape
firstContrast	First Contrast	Required. Finite number.
secondContrast	Second Contrast	Required. Finite number.
periodDifference	Period Difference	Required. Finite number.
sequenceImbalance	firstActive+secondControl-firstControl-secondActive, in outcome units.	Required. Finite number.

json

{
  "input": {
    "firstActive": 10,
    "firstControl": 8,
    "secondActive": 12,
    "secondControl": 9
  },
  "output": {
    "firstContrast": 2,
    "secondContrast": 3,
    "periodDifference": 1.5,
    "sequenceImbalance": -1
  }
}

Limitations and assumptions

All four inputs need one outcome scale and a defined period/sequence mapping. These are supplied aggregate contrasts, not a fitted crossover model, variance estimate, carryover test, or evidence of efficacy.
Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Signed zero is exported as zero.

Alternative or Complementary methods

Use a substantive source and study appraisal for clinical claims. Verify methods, preregistration, reporting, comparator conditions, and measurement validity beyond matching labels or calculated completeness.

References

Calculation and input contract: osteopathy/osteopathic-study-crossover-period-imbalance — tool.io

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Osteopathic Study Consent Withdrawal Date
Return sinceEntry=assessmentDay-entryDay, afterWithdrawal using >= if inclusiveWithdrawal otherwise >, and eligible only when on/after entry and not after withdrawal under that policy.
Osteopathic Study Control Time Share
Return uniqueContact=active+sham-shared, activeShare=active/total, shamShare=sham/total, and remaining=total-uniqueContact.