Normalized Amygdala Volume Calculator

Actual bilateral amygdala/ICVfraction with independently matched segmentation convention, not hippocampal adjustment or clinical size norm. Independently measured compatible definitions/units required; ratio is not a diagnosis, efficacy measure or safety/clinical threshold.

Description

Normalized amygdala volume relates a bilateral segmented volume to intracranial volume.

Normalized amygdala volume relates a bilateral segmented volume to intracranial volume.1

The resulting ratio does not adjust for all demographic or acquisition differences.

When to use Normalized Amygdala Volume Calculator

Use this tool to calculate or review the supplied observations under the stated rules. Establish the assessment or recording protocol, units, instrument version and independently applicable reference or calibration.

How to use Normalized Amygdala Volume Calculator and understand its results

  1. Establish the assessment or recording protocol, units, instrument version and independently applicable reference or calibration.
  2. Enter independentlySegmentedBilateralAmygdalaVolumeMl, independentlyMatchedIntracranialVolumeMl, using the field meanings and rules below, then run the tool.
  3. Read result.observedRatio. Use the units and sign conventions below.
  4. Correct any reported input issue and run again. Before using a successful result, check the stated units, signs, reference scope and observation coverage.
Input fieldMeaningValue typeRequirement
independentlySegmentedBilateralAmygdalaVolumeMlIndependently segmented bilateral amygdala volume mlnumberRequired
independentlyMatchedIntracranialVolumeMlIndependently matched intracranial volume mlnumberRequired

Supply a nonnegative independentlySegmentedBilateralAmygdalaVolumeMl and strictly positive independentlyMatchedIntracranialVolumeMl. Divide the first by the second for a dimensionless ratio. The general ratio calculation does not clamp the result or require the numerator to be no greater than the denominator; a larger numerator can return above one. Establish matching observation scope and units independently.

observedRatio=1×independentlySegmentedBilateralAmygdalaVolumeMl/independentlyMatchedIntracranialVolumeMl

Use the matching field units and the exact boundary, ordering and reference rules above.

Output fieldMeaningValue type
resultStructured result; its nested fields below contain the actual calculation or selected referenceobject
result.observedRatioObserved Ratio; dimensionless ratio, without percent scalingnumber
json
{
  "input": {
    "independentlySegmentedBilateralAmygdalaVolumeMl": 2,
    "independentlyMatchedIntracranialVolumeMl": 4
  },
  "output": {
    "result": {
      "observedRatio": 0.5
    }
  }
}

Limitations and assumptions

Actual acquisition, assessment protocol, instrument version and calibration determine applicability. The tool does not examine a person, classify images, administer a questionnaire or choose diagnostic cutoffs.

Missing required fields, unknown fields, wrong types and violated rules return input issues. Numeric values and outputs must be finite. Extremely large composite outputs are rejected.

Alternative or Complementary methods

For a related step, use White Matter Fraction Calculator: White-matter fraction expresses a segmented volume relative to a matched intracranial volume. For a complementary comparison, use Gray Matter Fraction Calculator: Gray-matter fraction compares a segmented gray-matter volume with matched intracranial volume.

References

  1. Normalized Amygdala Volume Calculator — tool.io

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