Exclusion Mismatch Tolerance

Count exact diploid STR genotype mismatches against a caller-defined tolerance; not a paternity conclusion.

Description

Exact diploid genotype agreement can be audited across STR loci.

Exact diploid genotype agreement can be audited across STR loci. Allele ordering within an unphased pair should not create a mismatch.

Count exact diploid STR genotype mismatches against a caller-defined tolerance; not a paternity conclusion.

When to use Exclusion Mismatch Tolerance

Use this for the following task: Count exact diploid STR genotype mismatches against a caller-defined tolerance; not a paternity conclusion.

Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.

How to use Exclusion Mismatch Tolerance and understand its results

Prepare the observed records or explicit model parameters requested below. Keep probabilities as fractions and paired records aligned.
Enter locusNames, firstAlleles, secondAlleles, maximumMismatches using the field table, then run the tool.
Read mismatchedLoci, mismatchCount, withinTolerance. Interpret flags, units, ordering and placeholder values using the rules below.
Review any reported issue or failed check, correct the supplied values when appropriate, and verify the result in its intended context.

Input field	Meaning	Value type and bounds	Requirement
locusNames	Locus names	list of string; each entry: string	Required
firstAlleles	First alleles	list of string; each entry: string	Required
secondAlleles	Second alleles	list of string; each entry: string	Required
maximumMismatches	Maximum mismatches	integer	Required

Align locus names and explicit two-allele slash-separated calls. Trim individual alleles, sort each pair and compare exact normalized strings.^[1]

mismatch if sorted trimmed allele pairs differ; withinTolerance = mismatches ≤ maximum

This summarizes the declared operation. Units, indexing, inclusivity and exceptional cases are explained in the surrounding text.

Output field	Meaning	Value type
mismatchedLoci	Mismatched loci	list of string
mismatchCount	Mismatch count	number
withinTolerance	Within tolerance	boolean

json

{
  "input": {
    "locusNames": [
      "A",
      "B",
      "C"
    ],
    "firstAlleles": [
      "12/13",
      "10/11",
      "8/9"
    ],
    "secondAlleles": [
      "12/13",
      "10/10",
      "8/9"
    ],
    "maximumMismatches": 1
  },
  "output": {
    "mismatchedLoci": [
      "B"
    ],
    "mismatchCount": 1,
    "withinTolerance": true
  }
}

Limitations and assumptions

Different spellings remain distinct. This is genotype equality, not parent-child compatibility, a paternity conclusion or a probabilistic identity test.

The tool evaluates supplied observations or a declared model. It does not establish the biological cause of an observed pattern. Malformed requests produce input errors. A successfully evaluated request can still contain false flags, empty result lists or a result outside the supplied threshold; those outcomes have the meanings stated above.

Alternative or Complementary methods

Choose Multilocus Genotype Match for this operation: Calculate theta-adjusted genotype match probabilities and their independent-locus product and log score. For a complementary task, use STR Panel Completeness for this operation: Audit STR panel completeness against a caller-supplied locus set, not an embedded legacy policy.

The implementation reference documents the exact calculation, supported input shapes and returned fields.

References

Exclusion Mismatch Tolerance — tool.io

Similar or alternative tools

Multilocus Genotype Match
Calculate theta-adjusted genotype match probabilities and their independent-locus product and log score.
STR Panel Completeness
Audit STR panel completeness against a caller-supplied locus set, not an embedded legacy policy.