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Sequence Fitness One Locus Contribution Tool

Diploid additive-on-fitness coding gives heterozygote h*s and variant homozygote s; parameters are supplied rather than inferred from sequence.

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Description

Return one diploid locus's supplied fitness contribution.

Biological growth and substitution models encode specific assumptions about rates, interactions and state spaces. Evaluating their formula at one supplied state can illustrate the model without fitting parameters, integrating a trajectory or establishing that its assumptions hold for real observations.

Return one diploid locus's supplied fitness contribution.

When to use this tool

Use Sequence Fitness One Locus Contribution when evaluating the stated biological rate or substitution-model term under its declared assumptions.

How to use the tool and how it works

  1. Enter referenceFitness, effect, dominance, alleleCopies. Use the units and conventions below.
  2. Run the tool. Correct any format, range, or cross-field input error before interpreting the output.
  3. Read contribution, resultingFitness. Use the output convention below.

Return one diploid locus's supplied fitness contribution. Require alleleCopies 0..2 and dominance in [0,1]; contribution is zero, effect*dominance or effect, then add referenceFitness.1

Input fieldMeaning and unitsAccepted input
referenceFitnessReference FitnessRequired. Finite number.
effectEffectRequired. Finite number.
dominanceDominanceRequired. Finite number; minimum 0; maximum 1.
alleleCopiesAllele CopiesRequired. Safe integer; minimum 0; maximum 2.
Output fieldInterpretationReturned shape
contributionContributionRequired. Finite number.
resultingFitnessResulting FitnessRequired. Finite number.
json
{
  "input": {
    "referenceFitness": 1,
    "effect": 0.2,
    "dominance": 0.5,
    "alleleCopies": 1
  },
  "output": {
    "contribution": 0.1,
    "resultingFitness": 1.1
  }
}

Limitations and assumptions

  • This is an additive supplied model; negative resulting fitness is not clipped and no genotype effect is estimated.
  • Inputs must satisfy both the field types and the cross-field conditions above. Invalid input causes an error; a successful false flag or documented placeholder is a different result.
  • Numeric calculations use binary floating point unless exact decimal-integer arithmetic is explicitly stated. No hidden measurement tolerance or decimal rounding is added; nonfinite or out-of-contract results are rejected. Numeric signed-zero results are exported as zero.

Alternative or Complementary methods

Fit and validate an appropriate complete model against relevant data, with parameter, time-unit and numerical-error checks for biological inference.

References

  1. Calculation and input contract: computational-biology/sequence-fitness-one-locus-contribution — tool.io

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